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Cytological Grading of Breast Carcinoma on FNAC & Correlation with Histological Grading on Excised Specimen

Bargir Umair Ahmed N.A. , Neethu G.V.* , Bargir Umair Ahmed N.A.** , Hiremath S.S.*** , Patil S.B.***

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Indian Journal of Cancer Education and Research 5(1):p 25-28, January - June 2017. | DOI: DOI: http://dx.doi.org/10.21088/ijcer.2321.9815.5117.4

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Abstract

 Background: With the advent of fine needle aspiration cytology (FNAC), the approach to diagnosis and management of breast lesions has been revolutionized. Assigning a tumor grade to breast cancer provides important prognostic information and guides optimal therapy. Aim: The aim of this study was to grade breast carcinoma on aspirates by Robinson Grading System (RGS) and histological grading was done according to Nottingham modification of Scarff–Bloom–Richardson method. Materials and Methods: Over a period of 2.5 years, 109 cases diagnosed as malignant on FNAC of clinically palpable lesions, were included & non-epithelial tumours are excluded. A total of 47 cases were followed-up by histopathologic examination. Results: Robinson’s cytological grading correlated well with Bloom Richardson’s histopathological grading. In the present study, by application of Chi-square test, p value was <0.00001 which is statically significant. This indicates that cytological and histopathological grade are well correlated. Conclusion: Cytologic grade could be used to predict histologic grade as significant relationship exists between grades assigned to cytologic and histologic specimens. Evaluation of cytology grade using FNAC permits determination of the aggressiveness of breast carcinoma.

Keywords: Breast Carcinoma; Cytologic Grading; Histologic Grading.

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DOI: DOI: http://dx.doi.org/10.21088/ijcer.2321.9815.5117.4

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