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Cutaneous Manifestations In Relation to All Malignancies: A Retrospective and Prospective Study

Virendra Bhandari , Jayant P S Yadav1 , Vividha Dubey2 , Yusuf Malik3 , Kailash Bhatia4 , Saurabh Karnawat5 , Virendra Bhandari6

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Indian Journal of Cancer Education and Research 9(1):p 17-23, January-June 2021. | DOI: http://dx.doi.org/10.21088/ijcer.2321.9815.9121.2

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Jayant P.S. Yadav, Vividha Dubey et al./Cutaneous manifestations in relation to all malignancies: a retrospective and prospective study/ Indian J Canc Educ Res 2020;9(1):17-23.

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Abstract

Introduction: Cutaneous manifestations may be primary to a hidden primary condition or it can also be secondary to an underlying malignancy. An association between systemic malignancy and cutaneous manifestations has long been recognized. Metastasis to the skin is easily visible and can be detected by the physician with relative ease which enhances and emphasizes the role of the clinician in appreciating various appearance of these lesions. With increase in the incidence of cancer in India in the past few decades, it is essential to recognize neoplasms at early stages Materials and Methods: Retrospective and prospective study was performed on 60 confirmed cases of all malignancies with cutaneous manifestations. Data regarding skin manifestation and malignancies were recorded from duration January 2017 to December 2019. Results: Most of the patients were above 60 years with no sex discrimination. Most common cutaneous marker was paraneoplastic dermatoses (82%) followed by nonspecific manifestations in (18%). Most common cutaneous presentation were generalized pruritus (42%) followed by infections (22%), seborrheic keratosis (20%), xeroderma pigmentosum (8%) and generalized xerosis (8%). In males respiratory tract malignancies (42%), Gastro intestinal malignancies (30%), lymphomas (22%) and leukemias (6%) were main malignancies with skin manifestations and in females reproductive tract malignancies (48%), Carcinoma breast (30%) and oral cavity cancer (22%) were common. Conclusion: Cutaneous manifestation from all malignancies is a relatively uncommon phenomenon but at times, they may be the only presenting feature. Cutaneous paraneoplastic syndromes are important clinical markers that may precede or occur simultaneously or after the diagnosis of a given neoplasm and recognizing them may lead to a higher chance of cure and better prognosis for the patient.

Keywords: Cutaneous Manifestation; Cancer; Paraneoplastic Syndromes

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Jayant P.S. Yadav, Vividha Dubey et al./Cutaneous manifestations in relation to all malignancies: a retrospective and prospective study/ Indian J Canc Educ Res 2020;9(1):17-23.

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DOI: http://dx.doi.org/10.21088/ijcer.2321.9815.9121.2

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