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Correlation between Serum High Sensitivity C-reactive Protein Level and Severity of Coronary Atherosclerosis Assessed by Angiographic Gensini Score in Patients with Acute Coronary Syndrome

Priyanka Kiyawat, Assistant Professor, MGM Medical College & M.Y. Hospital, Indore, Madhya Pradesh 452001, India. , Mayank Jain , Priyanka Kiyawat , Surbhi Kiyawat ,

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Journal of Cardiovascular Medicine and Surgery 4(2):p 100-107, April-June 2018. | DOI: http://dx.doi.org/10.21088/jcms.2454.7123.4218.5

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Abstract

Background and Objectives: Atherosclerosis is now known to be an active process of cell activation, inflammation and thrombosis [1]. To study, whether there is any correlation between the serum hs­ CRP level, a biomarker of inflammation, and the angiographic severity and extent of coronary artery lesion in patients with acute coronary syndrome, such studies are sparse in India.

Methods: Patients with ACS who were fulfilling the inclusion criteria, were enrolled prospectively in the study during the period February 2017 to February 2018. The patients were further classified three risk groups according to serum hs­CRP levels. < 1 mg/L ­ low risk, 1­3 mg/L ­ average risk and >3 mg/ L­ high risk. The presence and extension of CAD was assessed according to the modified Gensini scoring system. Mean angiographic Gensini scores were compared among the serum hs­CRP risk groups using ANOVA as the test of significance. Direct correlation between angiographic Gensini scores and serum hs­CRP levels were assessed using Pearson’s correlation (2­tailed). A cut­off p value of < 0.05 was set for results to be statistically significant. Independent predictors of Gensini score were assessed with multiple regression analysis.

Results: A total of 100 patients, with diagnosis of ACS, The mean angiographic Gensini scores significantly associated with the plasma hs­CRP, it showed increasing trend from lower to higher serum hs­CRP risk groups, and high serum hs­CRP was independently associated with Gensini score.

Conclusion: Our study found that the severity of coronary atherosclerosis significantly associated with the concentration of the plasma hs­CRP and the mean angiographic Gensini scores, also showed increasing trend from lower to higher serum hs­CRP risk groups. Moreover, high serum hs­CRP was associated with Gensini score independent of age, sex, smoking status, hypertension, diabetes, dyslipidemia and Family history of CAD/CVdeath.


 

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DOI: http://dx.doi.org/10.21088/jcms.2454.7123.4218.5

Keywords

Coronary Atherosclerosis; Angiographic Gensini Score; Acute Coronary Syndrome.

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