Abstract

Many medications are now administered orally; however they are not as effective as they should be. Beyond the local application site, transdermal delivery technology is being explored to treat a wide range of diseases. Because of reduced first pass metabolism, avoidance of an adverse gastrointestinal environment, and the potential to provide extended and regulated drug delivery, transdermal drug administration offers substantial benefits over oral treatment. Transdermal drug delivery systems (TDDS) are topically applied patches that release medications for systemic effects at a predetermined and regulated rate. It works by putting a medication inside a patch and wearing it for a long time on the skin. As a result, a steady concentration of medication remains in the bloodstream for an extended period of time. TDDS products include Scopolamine, Nicotine, Testosterone, Fentanyl, and Clonidine. Numerous active compounds with variable molecular size and structure cannot be maintained in transdermal form, despite their many benefits.

• 1.   Vega-Vásquez P, Mosier NS, Irudayaraj J. Nanoscale drug delivery systems: from medicine to agriculture. Front Bioeng Biotechnol. 2020;8:79.
• 2.   Vargason AM, Anselmo AC, Mitragotri S. The evolution of commercial drug delivery technologies. Nat Biomed Eng. 2021.
• 3.   Mali AD, Bathe R, Patil M. An updated review on transdermal drug delivery systems. Int J Adv Sci Res. 2015;1(6):244–54.
• 4.   Li C, Wang J, Wang Y, Gao H, Wei G, Huang Y, et al. Recent progress in drug delivery. Acta Pharm Sin B. 2019;9(6):1145–62.
• 5.   Kumar JA, Pullakandam N, Prabu SL, Gopal V. Transdermal drug delivery system: An overview. Int J Pharm Sci Rev Res. 2010;3(2):49– 54.
• 6.   Jeong, W.Y., Kwon, M., Choi, H.E. et al. Recent advances in transdermal drug delivery systems: a review. Biomater Res 25, 24 (2021).
• 7.   Jain, N. K., Controlled and Novel Drug Delivery, CBS Publishers, and Distributors, 2002, 107.
• 8.   Reddy et al. “Transdermal Drug Delivery System: A Review.” Research Journal of Pharmaceutical Dosage Forms and Technology, vol. 5, no. 4, 2013, pp. 202-212.
• 9.   Stücker M, Struk A, Altmeyer P, Herde M, Baumgärtl H, Lübbers DW (February 2002).
• 10.   https://en.wikipedia.org/wiki/Human_ skin#cite_note-St%C3%BCcker2002-13.
• 11.   Dr. B.Arul and Dr. R. Kothai, Noval Drug Delivery System, edition 2020, S.vikas and Company (Medical Publisers).
• 12.   Otberg, N.; Patzelt, A.; Rasulev, U.; Hagemeister, T.; Linscheid, M.; Sinkgraven, R.; Sterry, W.; and Lademann, J. The role of hair follicles in the percutaneous absorption of caffeine. Br. J. Clin. Phamacol. 2007; 65: 488-492.
• 13.   Transdermal patch, Wikipedia, 06-Apr-2017. [Online].Available: https://en.wikipedia.org/ wiki/Transdermal_patch. [Accessed: 03-Apr- 2017].
• 14.   Lewis et al. Design and Evlauation of Matrix Type and Membrane Controlled Transdermal Delivery Systems of Nicotine Suitable for use in Smoking Cessation. Indian Journal of Pharmaceutical Sciences, 2006, pp. 179-184.
• 15.   Marjukka Suhonen TA, Bouwstra J. Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations. J Control Release 1999:59:149-161.
• 16.   https://www.nursingtimes.net/clinicalarchive/dermatology/skin-1-the-structureand-functions-of-the-skin-25-11-2019/
• 17.   https://biotextiles2017blog.wordpress.com/transdermal-patch/

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