Abstract

Wolf’s isotopic response refers to the occurrence of a new dermatosis at the site of a previously healed and unrelated skin condition. While commonly associated with viral triggers such as herpes simplex or zoster, non-viral initiators are rarely reported. We present two unique cases of psoriasis developing exclusively at sites of old scars from non-viral causes. The first case involved a 33-year-old male who developed a psoriatic plaque over a thermal burn scar on the dorsum of the hand. The second case featured a 28-year-old male with psoriatic lesions localized to an atrophic scar following a traumatic injury to the shin. Both cases lacked involvement of other body areas. Diagnosis was confirmed by clinical features, dermoscopy, and histopathology. These cases highlight an atypical presentation of Wolf’s isotopic phenomenon and underscore the potential role of localized immune dysregulation and scar-mediated vulnerability in the development of secondary dermatoses.

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