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Pediatric Education and Research 13(2 (Special Supplement -II)):p 409-410, July-Dec 2025. | DOI: https://doi.org/10.21088/per.2321.1644.13225.98
Review Article
Contribution of Dr. Eric Kandel in Field of Pediatrics
Nikita Madhav Padampente, Kasumbiwal Ajay H., Mangesh Dake, Tambe Pranita
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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Pediatric Education and Research 13(2 (Special Supplement -II)):p 409-410, July-Dec 2025. | DOI: https://doi.org/10.21088/per.2321.1644.13225.98
How Cite This Article:
Kasumbiwal Ajay H., Dake Mangesh V., Tambe Pranita, et al. Contribution of Dr. Eric Kandel in Field of Pediatrics. Pediatr. Edu. Res. 2025; 13(2): 409-410.Timeline
Received : December 23, 2025
Accepted : December 29, 2025
Published : December 30, 2025
Abstract
Eric R. Kandel is a pioneering neuroscientist whose work revolutionized the understanding of the biological basis of memory. This review highlights his seminal discoveries using the marine snail Aplysia californica, which demonstrated that learning and memory are stored as changes in synaptic strength.1-3 His research established that short-term memory involves functional synaptic modifications, whereas long-term memory requires gene activation, protein synthesis, and the formation of new synaptic connections.4-6 Central to this process is the transcription factor CREB, which acts as a molecular switch for memory consolidation.7 By linking molecular mechanisms to behavior, Kandel bridged psychology and biology, providing a unified framework for cognitive neuroscience. Awarded the Nobel Prize in Physiology or Medicine in 2000, Kandel’s work continues to influence research into neurodegenerative and psychiatric disorders.8-10
References
- 1. Kandel E.R. The molecular biology of memory storage: a dialogue between genes and synapses. Science. 2001; 294(5544): 1030–1038.
- 2. Kandel E.R. In Search of Memory: The Emergence of a New Science of Mind. New York: W.W. Norton; 2006.
- 3. Kandel E.R, Schwartz J.H., Jessell T.M. Principles of Neural Science. 4th ed. New York: McGraw-Hill; 2000.
- 4. Bailey C.H., Kandel E.R. Structural changes accompanying memory storage. Annu Rev Physiol. 1993; 55: 397–426.
- 5. Castellucci V.F., Kandel E.R. A quantitative analysis of the synaptic depression underlying habituation of the gill-withdrawal reflex in Aplysia. Proc Natl Acad Sci USA. 1974; 71(12): 5004–5008.
- 6. Dash P.K., Hochner B., Kandel E.R. Injection of CREB protein blocks long-term facilitation in Aplysia. Nature. 1990; 345: 718–721.
- 7. Alberini C.M. Transcription factors in longterm memory and synaptic plasticity. Physiol Rev. 2009; 89(1): 121–145.
- 8. Squire L.R., Kandel E.R. Memory: From Mind to Molecules. New York: Scientific American Library; 1999.
- 9. Mayford M., Siegelbaum S.A., Kandel E.R. Synapses and memory storage. Cold Spring Harb Perspect Biol. 2012; 4(6): a005751.
- 10. Dudai Y. The neurobiology of memory concepts, findings, trends. Oxford University Press; 2004.
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
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Cite this article
Kasumbiwal Ajay H., Dake Mangesh V., Tambe Pranita, et al. Contribution of Dr. Eric Kandel in Field of Pediatrics. Pediatr. Edu. Res. 2025; 13(2): 409-410.
Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
| Received | Accepted | Published |
|---|---|---|
| December 23, 2025 | December 29, 2025 | December 30, 2025 |
DOI: https://doi.org/10.21088/per.2321.1644.13225.98
Keywords
Eric KandelMemorySynaptic PlasticityAplysiaCREBLearningNeuroscienceNobel PrizeSearch for Similar Articles
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Timeline
| Received | December 23, 2025 |
| Accepted | December 29, 2025 |
| Published | December 30, 2025 |
licence
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
