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Case Report

Congenital Granular Cell Epulis Presenting as a Rapidly Growing Maxillary Mass in a Neonate

Sandip Kumar Rahul, Pallavi Suman, Nirmal Kumar

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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

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Pediatric Education and Research 14(1):p 27-29, January 2026. | DOI: https://doi.org/10.21088/per.2320.0022.14126.5

How Cite This Article:

Pallavi Suman, Nirmal Kumar, Sandip Kumar Rahul. Congenital Granular Cell Epulis Presenting as a Rapidly Growing Maxillary Mass in a Neonate. Pediatr. Edu. Res. 2026;14(1): 27-29.

Timeline

Received : January 22, 2026         Accepted : February 26, 2026          Published : June 26, 2026

Abstract

Congenital granular cell epulis (CGCE) is a rare benign tumor of the newborn arising from the alveolar ridge and occasionally causing feeding or airway difficulties. We report a case of a 19-day-old neonate who presented with a rapidly enlarging swelling arising from the upper jaw. Complete surgical excision was performed. Histopathological examination revealed characteristic granular cells, and immunohistochemistry showed positivity for CD68 and S-100 protein, confirming the diagnosis of CGCE. Although the management of CGCE is simple and the lesion is benign, it can cause severe feeding difficulties and anesthetic concerns during airway management. The case highlights diagnostic features, surgical management, and anesthetic challenges associated with neonatal oral tumors.


References

  • 1.   Rauniyar D, Upadhyaya C, Chaurasia N, Sharma S, Bhandari A. Congenital epulis: a rare diagnosis of newborn. J Surg Case Rep. 2023 Aug 9;2023(8): rjad453.
  • 2.   Guidone PC, Seccia R, Fabrocini LA, Troiano G, Maffei G, Pedicillo MC, Pannone G, Lo Muzio L, Zamparese R, Mori G, De Stefano IS. Congenital granular cell epulis in a neonate: a case report and review of diagnosis, treatment, and prognosis. Front Oral Health. 2025 Aug 11; 6:1548291.
  • 3.   Gan J, Shi C, Liu S, Tian X, Wang X, Ma X, Gao P. Multiple congenital granular cell tumours of the maxilla and mandible: a rare case report and review of the literature. Transl Pediatr. 2021 May;10(5):1386-1392.
  • 4.   Reinshagen K, Wessel LM, Roth H, Waag KL. Congenital epulis: a rare diagnosis in paediatric surgery. Eur J Pediatr Surg. 2002 Apr;12(2):124-6.
  • 5.   Vered M, Dobriyan A, Buchner A. Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult. Virchows Arch. 2009 Mar;454(3): 303-10.
  • 6.   Avalos HS, Manci E, Mulekar M, Finnegan A, Barui S, Galliani C, Kelly D, Herrera GA. Congenital granular cell epulis: 24 new cases with more differences than similarities to granular cell tumor. Ultrastruct Pathol. 2022 Jul 4;46(4):388-400.
  • 7.   Singh A, Ghosh S, Yadav AK, Panthee A. Congenital granular cell tumor: Report of a case with literature review and differential diagnosis. Clin Case Rep. 2022 Mar 13;10(3):e05580.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.


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Cite this article

Pallavi Suman, Nirmal Kumar, Sandip Kumar Rahul. Congenital Granular Cell Epulis Presenting as a Rapidly Growing Maxillary Mass in a Neonate. Pediatr. Edu. Res. 2026;14(1): 27-29.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


Received Accepted Published
January 22, 2026 February 26, 2026 June 26, 2026

DOI: https://doi.org/10.21088/per.2320.0022.14126.5

Keywords

AirwayCongenital Granular Cell EpulisNeonateMaxillary MassImmunohistochemistry

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Received January 22, 2026
Accepted February 26, 2026
Published June 26, 2026

licence


Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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