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Comparison of Efficacy of Intravenous Paracetamol Versus Intravenous Tramadol for Postoperative Analgesia in Surgeries under General Anaesthesia

Anil Kumar Akkenapalli, Associate Professor, Gandhi Medical College/ Gandhi hospital, Secunderabad, Telangana 500003, India. , Anil Kumar Akkenapalli1 , Ashok Gunda2

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Indian Journal of Anesthesia and Analgesia 6(1):p 33-38, Jan-Feb 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6119.4

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Anil Kumar Akkenapalli & Ashok Gunda. Comparison of Efficacy of Intravenous Paracetamol Versus Intravenous Tramadol for Postoperative Analgesia in Surgeries under General Anaesthesia. Indian J Anesth Analg. 2019;6(1):33-38.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Introduction: The under treatment of postoperative pain is recognized as an important issue to the anesthesiologists and treating surgeons despite of improvement in mechanisms and introduction of acute pain services. Aim: To compare analgesic properties of Intravenous Paracetamol and Tramadol for postoperative analgesia in lower abdominal surgeries under general anesthesia. To study the adverse effects of Tramadol and Paracetamol. Materials and methods: It is a randomized study done in 100 patients ASA grade 1 and 2 of either sex, 20 to 60 years of age who underwent lower abdominal surgery under general anaesthesia. It was conducted to compare the efficacy of IV Paracetamol and IV Tramadol for postoperative analgesia. Group 1 received Intravenous Paracetamol and group 2 Intravenous Tramadol 15 min before the end of the surgery and the study drug was administered every 6th hourly for 24 hours. Patients were monitored for pain at 0, 2, 4, 6, 8, 10, 12 and 24 hours postoperatively. Also the time of first dose of rescue analgesia and number of doses of rescue analgesia given was noted. Side effects like nausea and vomiting was also observed. Results: Found that the pain scores were significant at 2 hours and 4 hours (except in the early postoperative period) and pain scores decreased over time in both the groups. About 60% of the patients in the Tramadol group had nausea and vomiting sensation at 0 hours, 12% at 2 hours, 14% at 4 hours, 48% at 6 hours, 26% at 8 hours respectively whereas in Paracetamol group about 4% of the patients had nausea at 2 hours, 4% at 4 hours and 2% at 6 hours. The rescue analgesia in the form of morphine was required in 22% of the patients of Paracetamol group at 0 hour, 32% at 2 hours and 2.0% at 10 hours after surgery. But Tramadol group required additional rescue analgesia in 10% of the patients. Total doses of rescue analgesic required by the Paracetamol group was 1.04 (± 0.2) and in group 2 (Tramadol) was 1.0 (± 0). There was no significant difference between Paracetamol and Tramadol groups. Conclusion: Paracetamol is as effective as Tramadol when used for postoperative pain relief in patients for lower abdominal surgeries except in the early postoperative period.  

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Anil Kumar Akkenapalli & Ashok Gunda. Comparison of Efficacy of Intravenous Paracetamol Versus Intravenous Tramadol for Postoperative Analgesia in Surgeries under General Anaesthesia. Indian J Anesth Analg. 2019;6(1):33-38.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6119.4

Keywords

Tramadol; Paracetamol; Postoperative analgesia. 

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