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Comparison of Effects of Oral Ivabradine and Oral Clonidine as Premedicants on Intraocular Pressure Changes Following Intubation with Succinylcholine

Aasim Ahmad , Mohd Asim Rasheed , Kriti Nagar , Aasim Ahmad , Raj Bahadur Singh

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Indian Journal of Anesthesia and Analgesia 7(1):p 291-297, January-February 2020. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7120.40

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Mohd Asim Rasheed, Kriti Nagar, Aasim Ahmad et al. Comparison of Effects of Oral Ivabradine and Oral Clonidine as
Premedicants on Intraocular Pressure Changes Following Intubation with Succinylcholine. Indian J Anesth Analg. 2020;7(1 Part
-II):291-297.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

 

Background: Endotracheal intubation done with succinylcholine raises intraocular pressure which can be of significance in cases of traumatic open globe injury. Aims: The study was done to compare the efficacy of oral Ivabradine and Clonidine in lowering the intraocular pressure rise following intubation using succinylcholine. Methods: A total of 105 patients were enrolled. Three groups having 35 patients each were formed. Group I: Received oral Ivabradine 5 mg, Group II: Received oral Clonidine 0.1 mg & Group III received placebo one hour before intubation. Intraocular Pressure (IOP) was measured with schiotz tonometer preoperatively & at various intervals to assess the effect of clonidine and Ivabradine on IOP. Results: A total of 105 pateints were
enrolled. Three groups having 35 patients each were formed. The mean IOP of the patients from 3 groups were comparable initially (p - 0.082). At all later time points, the mean IOP of patients from 3 groups was
statistically different (p < 0.001). The mean IOP in patients who received clonidine was significantly lesser as compared to control group at all time points except at the baseline (p < 0.001). However, among patients
who received Ivabradine, the mean IOP was significantly less than the control group only at T1, and T7.Conclusions: Oral Clonidine can be  recommended as premedicant for obtunding the rise in IOP following
endotracheal intubation using succinylcholine. Oral Ivabradine showed no effect on IOP during endotracheal intubation using succinylcholine.

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Cite this article

 

Mohd Asim Rasheed, Kriti Nagar, Aasim Ahmad et al. Comparison of Effects of Oral Ivabradine and Oral Clonidine as
Premedicants on Intraocular Pressure Changes Following Intubation with Succinylcholine. Indian J Anesth Analg. 2020;7(1 Part
-II):291-297.

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Received Accepted Published
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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7120.40

Keywords

Clonidine; Ivabradine; Succinylcholine; Intraocular pressure.

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