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Comparative Study of Analgesic Efficacy of Ropivacaine with Ropivacaine plus Dexmedetomidine for Epidural Block in Abdominal Hysterectomy Surgery

Rakesh Karnawat* , Rakesh Karnawat* , Ghansham Biyani** , Sadiq Mohammed*** , Meenal Agarwal****

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Indian Journal of Anesthesia and Analgesia 2(1):p 47-52, Jan-Jun 2015. | DOI: https://dx.doi.org/10.21088/ijaa.2349.8471.2115.6

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Abstract

Background: Efforts to find a better adjuvant in regional anaesthesia are underway since long.Aims and objectives are to compare the efficacy of epidural block with ropivacaine or ropivacaine plus dexmedetomidine for relief of post operative pain in patients undergoing abdominal hysterectomy surgery. Methodology: Sixty adult patients of ASA grade I & II, undergoing abdominal hysterectomy surgery were included in this prospective, randomized study. After placing the catheter in L1-L2 epidural space, block was randomly activated either by 18 ml of ropivacaine 0.25% (Group I) or by 18 ml of ropivacaine 0.25% plus 1µg/kg dexmedetomedine (Group II). General anaesthesia was instituted in all patients using a standardised technique. After recovery from GA, pain was assessed by VAS. The patients were administered first top up dose through epidural route as soon as VAS score exceeded 3 and time was noted for duration of analgesia. Total requirement of ropivacaine in 24 hours was also noted. Result: Mean duration of analgesia was longer in Group II (318.14±54.35 min) as compared to Group I (146.21 ±30.64 min) (p<0.05). Mean total consumption of ropivacaine was 89.42±12.32 mg in Group II and 122.36(14.26) mg in Group I (p< 0.05). Conclusion: Addition of dexmedetomidine to local anaesthetic agent ropivacaine significantly prolongs the duration of analgesia in epidural blocks.

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DOI: https://dx.doi.org/10.21088/ijaa.2349.8471.2115.6

Keywords

Epidural block; Ropivacaine; Dexmedetomidine; Abdominal hysterectomy surgery; Postoperative pain.

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