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Comparative Evaluation of the Effects of Combinations of FentanylPropofol with Ketamine-Propofol in Short Gynaecological Day Care Procedures: A Randomised Double Blind Study

Girijanandan D. Menon, Assistant Professor, Department of Anaesthesiology, M.O.S.C. Medical College, Kolenchery, Kochi, Kerala 682311, India. , Girijanandan D. Menon1 , Thankam P.2

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Indian Journal of Anesthesia and Analgesia 5(9):p 1502-1510, September 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5918.12

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Abstract

The advantages of ambulatory surgery is effective when patients get the benefits of day care anaesthesia.This is possible by using rapid acting intravenous anaesthetic agents.

Aim: Comparative the effects of combinations of fentanyl -propofol with ketamine propofol in short gynaecological procedures. The null hypothesis was that there is no difference between the two groups.

Objective: Primary outcome: To compare the induction dose and top up doses of propofol in the two groups, one pretreated with fentanyl and the other group pretreated with ketamine. Secondary outcome studied were the quality of immediate and intermediate recovery measured by time to eye opening, time to sit up and walk in the two groups.

Materials and Methods: A randomised double blind study was conducted with Institutional review board and ethics committee approval. Forty ASA I and II physical status females with written informed consent for dilatation and curettage underwent the study. They were allocated to two groups by odd/even numbers by randomisation and blinded by by sealed cover method. Group I (F) received fentanyl citrate 1.5 microgram/kg intravenously and Group II (K) received ketamine 0.5mg/kg intravenously. Both groups of patients were induced two minutes later with tirated dose of propofol. In both groups anaesthesia was maintained with incremental doses of 25 mg propofol. The data was anlysed using unpaired t test.

Results: The mean induction time and the total dose of propofol was more in the F group. The time taken for eye opening was shorter in group F.

Conclusion: Anaesthesia with propofol-fentanyl was comparable with propofol-Ketamine for out patient anaesthesia. Recovery is rapid with fentanyl, with out emergence delirium and total absence of emetic sequelae.


 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5918.12

Keywords

Outpatient Anaesthesia; Fentanyl; Propofol; Ketamine; Total Intravenous Anaesthesia; Early Recovery; Short Gynaecological Procedures.

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