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Buccal Smear Examination for Barr Bodies as Sex Determination Tool: Is it a Redundant Exercise?

Jayaben S. Charania* , Jayaben S. Charania* , Shanta Hattangdi**

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Indian Journal of Anatomy 5(3):p 329-333, Sept - Dec 2016. | DOI: DOI: http://dx.doi.org/10.21088/ija.2320.0022.5316.24

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Abstract

 Neuroanatomists Murray Barr and Ewart Bertram in 1949 provided first study on sex chromatin, later named as Barr body. This led to a theory proposed by Mary F. Lyon in 1961 called as “Lyon hypothesis”. Since then the Barr body from buccal smear is used as a sex determination tool. However, with advent of modern molecular methodologies it is labeled as a useless tool by some investigators. Authors of this article wish to stress the importance of Barr body examination as a low cost effective tool.

Keywords: Sex Chromatin; Barr Body; Amenorrhea; Inguinal Hernia; Turner Syndrome.

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DOI: DOI: http://dx.doi.org/10.21088/ija.2320.0022.5316.24

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