Abstract

Background: Kalanchoe pinnata, an important medicinal plant of the stonecrop family, is widely distributed in India and tropical and subtropical parts of the world. It has been reported for its folkloric use in various disorders such as abdominal discomfort, boils, bruises, cholera, cuts, diabetes, diarrhea dysentery, flatulence, headaches, kidney stones, indigestion, insect bites, scabies, sores, urinary insufficiency, wounds. Results: The present review has focused on the botanical description, phytochemistry, and ethnomedicinal and traditional uses of Kalanchoe pinnata along with its reported pharmacological activities. Chief chemical constituents and pharmacological aspects of Kalanchoe pinnata have been deeply explored to unravel the unexplored folklore/ ethnomedicinal uses of this plant so that the researchers working on this plant may be able to find new insights to continue the further investigation on this plant. The pharmacological aspects like anti-diabetic, anti-inflammatory, anti-nociceptive, anti-diarrheal, anti-pyretic, and anti-cancer potentials evaluated by various in vitro/in vivo methods on this plant have been reported. Conclusion: Various traditional uses have been reported that need to be scientifically investigated in-depth and several pharmacological activities have been reported for the Kalanchoe pinnata, but more detailed and mechanismbased studies linked to a particular lead compound need to be targeted in the future. Moreover, this plant has not been completely assessed based on its safety and efficacy in humans. It is expected that this review will compile and improve the existing knowledge on the potential utilization of Kalanchoe pinnata in complementary and alternative medicine.

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