Home > Journals > Indian Journal of Genetics and Molecular Research

Indian Journal of Genetics and Molecular Research

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Association of Monocyte Chemoattractant Protein (MCP) 1 gene 2518 A/G Polymorphism with Type2 Diabetic Nephropathy in South Indian Population

Yaongamphi Vashum , Yaongamphi Vashum , Md. S. Yasin , B. Thaslima , S. Shila*

Author Information

Licence:



Indian Journal of Genetics and Molecular Research 1(1):p 26-26, January - June 2012. | DOI:

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

 A promoter polymorphism (-2518 A/G) of Monocyte Chemoattractant Protein (MCP)-1 gene located on chromosome 17 have been studied in different ethnic population in various disease conditions including type 2 diabetes and its complication. The main aim of the present study was to examine the association of G allele frequency of A/G polymorphism of MCP1 gene in South Indian subjects with or without type2 diabetic nephropathy (DN). This study includes 75 diabetic subjects, 75 diabetic subjects with nephropathy and 85 healthy volunteers as control subjects. Genotyping of A/G polymorphism was performed by PCRRFLP method. The significant difference was found in age, body mass index, total cholesterol, high density lipoprotein cholesterol, triglyceride, urea and creatinine level, between the case and control subjects. GG genotypic frequency of A/G polymorphism was significantly higher in T2DM diabetic nephropathy subjects (26.67 % vs. 8.24%; P=0.001) than in T2DM s (13.33 % vs. 8.24 %; P=0.198) and control subjects. G allele frequency was higher in diabetic nephropathy group (49.33 %) than in control subjects (21.18 %). The result obtained in this study shows an increase in the frequency of G-A substitution in MCP-1 gene at position (- 2580) among south Indian type 2 diabetic nephropathy subjects.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI:

Keywords


Article Level Metrics

Last Updated

Monday 13 July 2026, 08:34:50 (IST)

1046

Accesses

5
310
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share