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Association of ADAM33 Gene Polymorphisms with Genetic Susceptibility to Asthma in Asian Populations: A Meta-Analysis

Priya Tripathi , Priya Tripathi , Shally Awasthi

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Indian Journal of Genetics and Molecular Research 2(1):p 11-21, January - June 2013. | DOI:

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Abstract

Method: The aim of present study was to assess the association of causative gene polymorphisms of ADAM33 in Asian population using Meta-analysis approach.We performed a literature search using the MEDLINE citation database and references in the identified reports. Data were analyzed using software Stata 11.2( Stata Corp, College Station, Texas, US). Thirteen studies and twelve ADAM33 gene polymorphisms were selected for meta-analysis, which included 3,270 patients and 2,922 controls. Results: On comparing data for “M” (Mutant allele) with the susceptibility to asthma as compared to the “L” (wild allele), four SNPs named as, S2, ST+5, T1 and Q-1 were observed to be associated with asthma. Likewise, on calculating “MM” (homozygous mutant genotype) vs “LL” (homozygous normal genotype), SNPs S2 and ST+5 showed association. After calculating, “LM” (heterozygous genotype) + “(MM vs LL)”, SNP ST+5 was found to be associated and lastly when we compared “MM” vs “(LL+LM)”, SNPs T1, S2 and ST+5 were found to be associated with asthma. Conclusion: To our knowledge, this is the first and most comprehensive genetic meta-analysis showing association of ADAM33 gene polymorphisms (Q-1, S2 and T1) with asthma in Asian population. 

Keywords: Asian population;  Meta-analysis; Single nucleotide polymorphisms; Association study; Case-control studies. 

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