Abstract

Objectives: Oral Squamous Cell Carcinoma (OSCC) is the most common cancer across the globe. The treatment of OSCC by surgery, chemotherapy, radiotherapy or any combination of these has an adverse effect on the Quality of Life (QOL) of the patients. The main aim of this study was to evaluate the Oral health related Quality of Life (OHRQOL) in OSCC patients after their treatment. Study Design: A cross sectional questionnaire study. Results: Data related to their Sociodemographic factors like age, gender, type of habit abuse, TNM stage of the cancer, and socioeconomic status were collected. After statistical analysis, it was found that patients who had the poorest quality of life were married males in age group of 41-50 years with a habit of tobacco+alcohol abuse. Also they belonged to Stage 4b and were undergoing treatment in form of chemotherapy+radiotherapy and they belonged to upper middle SES class of modified Kuppuswamy scale 2018. Conclusion: This study considers the significance of interplay of a constellation of factors that have an impact on quality of life in patients undergoing OSCC treatment. Physicians must consider the interplay of all these factors for making decision in treatment plan for the patient.

• 1.   Singh MP, Kumar V, Agarwal A, Kumar R, Bhatt MLB, Misra S. Clinico-epidemiological study of oral squamous cell carcinoma: A tertiary care centre study in North India. J Oral Biol Craniofacial Res. 2016; doi:10.1016/j.jobcr.2015.11.002.
• 2.   Indrapriyadharshini K, Madankumar PD, Karthikeyan GR. Oral health-related quality of life in patients treated for oral malignancy at Kanchipuram district, India: A cross-sectional study. Indian J Cancer 2017; doi: 10.4103/ijc. IJC_116_17
• 3.   Bhalla A, Anup N, Bhalla A, Singh SB, Gupta P. Oral Health Related Quality of Life (OHRQOL) Amongst Head and Neck Cancer Patients Undergoing Chemotherapy and Radiotherapy at SawiMansingh Hospital Jaipur , India 2015;3:3–12.
• 4.   Levin KA. Study design III: Cross-sectional studies. Evid Based Dent 2006;7(1):24–5. doi:10.1186/ s12955-014-0201-5
• 5.   Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health, Version. www.OpenEpi.com updated 2013/04/06. doi:10.1038/sj.ebd.6400375
• 6.   Rivera C, Venegas B. Histological and molecular aspects of oral squamous cell carcinoma (Review ) 2014;7–11. Doi:10.3892/ol.2014.2103
• 7.   Saleem SM. Modified Kuppuswamy Scale Updated For Year 2018 Original Research Paper Modified Kuppuswamy Scale Updated For. 2018;(March).
• 8.   Barrios R, Tsakos G, García-Medina B, MartínezLara I, Bravo M. Oral health-related quality of life and malnutrition in patients treated for oral cancer. Support Care Cancer. 2014;22(11):2927–33. doi:10.1007/s00520-014-2281-5
• 9.   William M. Lydiatt, MD1; Snehal G. Patel, MD2; Brian O’Sullivan, MD3; Margaret S. Brandwein, MD4; John A. Ridge, MD, PhD5; Jocelyn C. Migliacci, MA6 et al. Head and Neck CancersMajor Changes in the American Joint Committee on Cancer Eighth Edition Cancer Staging Manual Continuing Medical Education Accreditation and Designation Statement. CA Cancer J Clin [Internet]. 2017;67(2):122–37. doi:10.3322/caac.21389.
• 10.   Victorson D, Cella D, Wagner L, Kramer L, Smith M Lou. Measuring Quality of Life in Cancer Survivors. Handb Cancer Surviv. 2007;79–110.
• 11.   Mahler H. The constitutional mission of the World Health Organization. World Heal Organ Chron. 1974;28(7):308–11.
• 12.   Feller L, Lemmer J. Oral Squamous Cell Carcinoma: Epidemiology, Clinical Presentation and Treatment. J Cancer Ther. 2012;03(04):263–8. doi:10.4236/ jct.2012.34037
• 13.   Braue A, Dolianitis C, Varigos G. Spontaneous resolution of facial papularmucinosis in a transplant patient. Australas J Dermatol. 2008;49(3):164–6. doi: 10.1596/978-1-4648-0349-9
• 14.   Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla R V., Migliorati CA, et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017;6(12):2918–31. doi:10.1002/cam4.1221.
• 15.   Carneiro-Neto JN, de-Menezes JD da S, Moura LB, Massucato EMS, de-Andrade CR. Protocols for management of oral complications of chemotherapy and/or radiotherapy for oral cancer: Systematic review and meta-analysis current. Med Oral Patol Oral y Cir Bucal. 2017;22(1):e15–23.
• 16.   Bennadi D RCO health related quality of life. J of IS of P& CD 2013 J. doi:10.4317/medoral.21314
• 17.   Montero-Martin J, Bravo-Pérez M, AlbaladejoMartínez A, Hernández-Martin LA, RoselGallardo EM. Validation the Oral Health Impact Profile (OHIP-14sp) for adults in Spain. Med Oral Patol Oral Cir Bucal. 2009;14(1).
• 18.   Study P of oral cancer and pre-cancerous lesions and the association with numerous risk factors in NIA hospital based, Shalini Gupta, Rajender Singh, and AT. doi: 10.4317/medoral.22670
• 19.   Khandekar SP, Bagdey PS TRO cancer and some, Med epidemiological factors: A hospital based study. IJC, 2006;31:15-79.
• 20.   de Melo NB, de Sousa VM, Bernardino MM, de Melo DP, Gomes DQC, Bento PM. Oral health related quality of life and determinant factors in patients with head and neck cancer. Med Oral Patol Oral Cir Bucal. 2019;24(3):e281–9.
• 21.   Sankaranarayanan R. Oral cancer in India: an epidemiologic and clinical review. Oral surgery, oral medicine, oral pathology. 1990 Mar 1;69(3):325- 30. doi:10.1016/00304220(90)90294-3.
• 22.   Levin KA. Study design III: Cross-sectional studies. Evidence-based dentistry. 2006 Mar;7(1):24. doi:10.1038/sj.ebd.6400375
• 23.   Pannuci CJ. Identifying and Avoiding Bias in Research. PlastReconstr Surg. 2011;126(2):619–25. doi:10.1097/PRS.0b013e3181de24bc.