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An Observational Study to Compare Intrathecal Midazolam and Clonidine for Post Operative Analgesia in Patients Undergoing Elective Hernia Surgeries

Malini Mehta, Professor, Department of Anesthesiology, SBKS MI & RC, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara, Gujarat 391760, India. , Gandhi Gunjan P.1 , Malini Mehta2

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Indian Journal of Anesthesia and Analgesia 5(3):p 372-376, March 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5318.3

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Abstract

Background and Objectives: This observational study is designed to compare the intrathecal preservative free  midazolam and clonidine, used as an adjuvant with hyperbaric bupivacaine for post operative analgesia in patients undergoing elective hernia surgeries. Material & Methodology: The observational study was conducted on 60 patients (using formula for Estimation of mean difference) of ASA grade I/II aged between 20 and 55 years posted for elective hernia surgeries under spinal anaesthesia. Group BM (midazolam group)– 15mg 0.5% hyperbaric bupivacaine+2mg preservative free midazolam made 3.5 ml with normal saline and Group BC (clonidine group) –15mg 0.5% hyperbaric bupivacaine +30µg preservative free clonidine made 3.5ml with normal saline. Onset and duration of sensory and motor blockade, Duration of Analgesia, Hemodynamic changes, Postoperative analgesic consumption in 24 hrs, Side effects/Complications (if any) were recorded. Results: There was a statistically significant difference in onset of sensory & motor block (pvalue< 0.01), and Duration of sensory & motor block (p value< 0.01) in BM group than BC group. Duration of analgesia was significantly prolonged in BM group (351.6±39.1min) as compared to BC group (252.5±21.1 min) (p value<0.01). Conclusion: Addition of 2mg midazolam (preservative free) to 0.5% hyperbaric Bupivacaine as an adjuvant intrathecally leads to early onset of sensory and motor block, prolongation of duration of sensory and motor blockade and prolongation of duration of analgesia as compared to 30 µg clonidine (preservative free) without any side effects in both the groups.

 

 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5318.3

Keywords

 Bupivacaine; Intathecal; Clonidine; Midazolam. 

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