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Amide Based Mutual Prodrug: Synthesis and Antimicrobial Evaluation

Asif Husain , Asif Husain , Aftab Ahmad , Shah Alam Khan , Nadir Islam

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Journal of Pharmaceutical and Medicinal Chemistry 1(2):p 95-98, July - December 2015. | DOI:

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Abstract

 An amide-based mutual prodrug (NA-D) was synthesized by condensing nalidixic acid with dapsone with an aim of preparing a useful drug, which could show broad spectrum of antimicrobial activity. Its structure was established on the basis of elemental analysis, 1H NMR and Mass spectral data results. The mutual prodrug (NA-D) was also evaluated for in-vitro antibacterial and antifungal activity.

Keywords: Dapsone; Amide; Prodrug; Bacterial; Fungal.

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