Full Text (PDF)
Indian Journal of Anesthesia and Analgesia 7(3):p 829-834, May-June 2020. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7320.27
Original Article
A Study of Haemodynamic and Pharmacodynamic Effects of CisAtracurium and Vecuronium in Patients Undergoing Laparoscopic
Shilpa M Doshi , Nimisha A Tank , Shilpa M Doshi
Author Information
Licence:
Indian Journal of Anesthesia and Analgesia 7(3):p 829-834, May-June 2020. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7320.27
How Cite This Article:
Nimisha A Tank, Shilpa M Doshi. A Study of Haemodynamic and Pharmacodynamic Effects of Cis-Atracurium and Vecuronium
in Patients Undergoing Laparoscopic. Indian J Anesth Analg. 2020;7(3):829–834.
Timeline
Received : N/A
Accepted : N/A
Published : N/A
Abstract
Aim: To study the haemodynamic and pharmacodynamic effects of cis-atracurium and vecuronium. Settings and Design: Prospective, Randomized, Parallel group, Double blind study Plan of Study: After
institutional review board approval and informed written consent from patients, eighty patients undergoing laparoscopic appendicectomy were randomized into two groups. Group-C n=40 received loading dose of inj.
Cis-atracurium 0.15mg/kg and maintenance doses of 0.03mg/kg while Group-V, n=40 received loading dose of inj. Vecuronium 0.10mg/kg and maintenance doses of 0.02mg/kg. As premedication Inj. Ondansetron,
Glycopyrolate, Midazolam were administered followed by Inj. Propofol + Inj. Fentanyl + loading dose of assigned drug for induction & intubation of the patient. Maintenance of general anaesthesia was done with
O 2+N2O (50:50), Sevoflurane inhalation, and intermittent doses of assigned muscle relaxant drug according to PNS. The observations as time of onset of action, intubation time, time interval between loading and first maintenance dose, time interval between maintenance doses, extubation time, total number of drug dosage requiredand haemodynamic parameters were noted. Statistical analysis: Data were analysed by using repeated measure ANOVA and by Manwitney U test. Results: Time of onset of action and intubation time in Group- V
were significantly lower as compared to Group-C.Time interval between loading & first maintenance dose was comparatively higher in Group- C than Group- V. Time intervals between maintenance doses were
comparable among both the groups. When compared with Group-V, extubation time was shorter in Group-C. Conclusion: Cis-atracurium had a longer time of onset of action, longer duration of action, hence less doses were required for maintenance of anaesthesia, faster recovery as compared to Vecuronium. Both drugs were haemodynamically stable.
References
No records found.
About this article
Cite this article
Nimisha A Tank, Shilpa M Doshi. A Study of Haemodynamic and Pharmacodynamic Effects of Cis-Atracurium and Vecuronium
in Patients Undergoing Laparoscopic. Indian J Anesth Analg. 2020;7(3):829–834.
Licence:
| Received | Accepted | Published |
|---|---|---|
| N/A | N/A | N/A |
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7320.27
Keywords
Cis-atracuriumVecuroniumTrain of FourOnset of actionDuration of action & recovery.Search for Similar Articles
Similar Articles
- Anesthetic Management of a Two-Year-Old Child with Mucolipidosis using the I-gel...
- Ephemeral Tachyarrhythmia During Laparoscopy: An Enigma
- Threading the Needle between Clots and Grafts: Anaesthetic Challenges for Urgent...
- Tachyarrhythmia Ventricular Tachycardia Following Injection Neostigmine: A Rare...
- A Case of Persistent Atrial Fibrillation for Laparoscopic Cholecystectomy
Article Level Metrics
Last UpdatedSaturday 28 February 2026, 17:56:26 (IST)
1391
Accesses
1
246
00
Citations
NA
NA
NA
Download citation
Article Keywords
Keyword Highlighting
Highlight selected keywords in the article text.
Timeline
| Received | N/A |
| Accepted | N/A |
| Published | N/A |