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A Review on Inductively Coupled Plasma: Mass Spectrometry with Laser Ablation

Sai Datri A, Research Scholar, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India. , 1Sai Datri A , 2Nataraj KS , 3Lakshmana Rao A

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Journal of Pharmaceutical and Medicinal Chemistry 7(1):p 23-32, January – June 2021. | DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.7121.3

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Sai Datri A, Nataraj KS, Lakshmana Rao A, A Review on Inductively Coupled Plasma: Mass Spectrometry with Laser Ablation. J Pharmaceut Med Chem. 2021;7(1):23-32.
 

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Abstract

Inductively coupled plasma mass spectrometry (ICP-MS) is a kind of mass spectroscopy which is used in many diverse research fields such as earth, environmental, life and forensic sciences and in food, material, chemical, semiconductor and nuclear industries. In this sort of MS, Laser ablation (LA) ICP-MS is widely used to determine elements directly in virtually all types of solid samples with minimal sample preparation. UV lasers are widely used with ICP-MS because of their highly controllable spatial resolution (spot size) and relatively low cost. This technique is used to determine low-concentrations and even ultra-low-concentrations of elements. Atomic elements are lead through a plasma source where they become ionized. The high ion density and the high temperature in plasma provide an ideal atomizer and element ionizer for all types of samples and matrices introduced by a variety of specialized devices. Then, these ions are sorted on account of their mass. ICP-MS holds a distinctive position by virtue of its speed, sensitivity, dynamic range and elemental coverage. It can be considered as a viable alternative to ICP-Optical Emission Spectroscopy (OES) (also known as Atomic Emission Spectroscopy or AES) for fast measurement of higher concentration elements. At the same time, ICP-MS in many cases exceeds the detection capability of Graphite Furnace Atomic Absorption Spectroscopy (GFAAS) for the determination of trace and ultratrace elements (ng/L or ppt concentrations). One of the fastest growing areas of ICP-MS is in speciation measurement: the combination of chromatographic techniques with ICP-MS as a detector to determine the chemical form of elements in the sample. This review provides an overview of recent developments and abilities of inductively coupled plasma mass spectrometry (ICPMS) coupled with different separation techniques for applications in the field of analysis and also highlighted numerous technical improvements, over the past few years which helped to promote the evolution of ICP-MS to one of the most versatile tools for elemental quantification as Laser ablation (LA) ICP-MS. In particular, the benefits and possibilities of using state-of-the-art hyphenated ICPMS approaches for quantitative analysis applications. Keywords: Inductively couple plasma mass spectrometry; ICP-MS; Laser ablation; Hyphenated techniques; Quantification and Trace elements.

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Cite this article

Sai Datri A, Nataraj KS, Lakshmana Rao A, A Review on Inductively Coupled Plasma: Mass Spectrometry with Laser Ablation. J Pharmaceut Med Chem. 2021;7(1):23-32.
 

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DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.7121.3

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