Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

A Prospective Single Blind Randomized Study on Prevention of Postoperative Nausea and Vomiting with Palanosetron versus Ondansetron in Patients undergoing Laparoscopic Surgery

Thangavelu Swarnalingam, 45/F2 Sai Krupa Homes, Ganapathi Nagar 3rd Street, Urapakkam, Kancheepuram, Tamilnadu-603210, India. , Swarnalingam Thangavelu1 , Nazir Ahmed Mallick2 , Anu Karthiga Manoharan3

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 4(3):p 702-707, July - September 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4317.26

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Context: In the modern era of surgical field laparoscopic surgeries are more frequently performed than open surgeries. Postoperative nausea and vomiting is a common complaint encountered in the patients who have undergone laparoscopic surgeries because of pneumoperitoneum created by CO2. A number of anti-emetics are given as prophylactic agents to prevent postoperative nausea and vomiting. Among them 5-hydroxytrypatmine type 3 receptor antagonists are highly effective in prevention and treatment of PONV. With this background we conducted a study for evaluating the effectiveness of two 5-HT3 receptor antagonists in prevention of PONV in patients undergoing laparoscopic surgeries under general anesthesia. Aim: To compare the efficacy and safety profile of two 5 HT3 antagonists namely palonosetron and ondansetron in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgeries. Settings & Design: This was a prospective, randomized, single-blind comparative study. Sixty patients of age group between 18-60 years of Ameri can Society of Anaesthesiologists physical status class I and II undergoing laparoscopic surgeries were enrolled. They were randomly allocated into two groups namely Group A and B with 30 patients in each group. Group A received 0.075mg of injection palonosetron and Group B received 4mg of injection ondansetron intravenously 30 minutes before induction of anaesthesia. Statistical Analysis used: Statistical work up was performed using the SPSS version 16. Student’s t –test was used for quantitative data and Chi- square test was used for qualitative data. P value of less than 0.05 was found to be statistically significant. Results: The incidence of PONV in group A (palonosetron) was found to be 13% which is lesser than group B (ondansetron) where the incidence was 23%. The need for rescue antiemetic was also comparatively lesser in group A than group B. (23% vs 51%). The number of complete responders were 26 (86%) and 23 (76%) for palonosetron and ondansetron respectively. Conclusion: Palonosetron is effective antiemetic for preventing PONV during the late postoperative period while compared to ondansetron.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4317.26

Keywords

Palonosetron; Ondansetron; Postoperative Nausea and Vomiting; Laparascopy.

Article Level Metrics

Last Updated

Saturday 07 February 2026, 21:01:51 (IST)

1189

Accesses

0
194
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share