Abstract

Background: Chronic kidney disease (CKD) has a significant impact on a person’s social, emotional, and physical health. Understanding the factors influencing the health-related quality life and lifestyle (HRQoL) of this demographic is crucial for providing comprehensive patient care. Objectives: To investigate the main behavioral, psychological, clinical, and sociodemographic factors that affect HRQoL in CKD patients. Methods: 280 CKD patients who visited nephrology clinics at three tertiary hospitals participated in a cross-sectional study. The Kidney Disease Quality of Life (KDQOL-36) questionnaire was used to measure HRQoL. Information was gathered on lifestyle factors, laboratory parameters, comorbidities, sociodemographics, and psychological distress (as measured by the Hospital Anxiety and Depression Scale). To find independent determinants of HRQoL, multiple linear regression was employed. Results: Reduced HRQoL was significantly correlated with depression (β = -0.42, p < 0.001), unemployment (β = -0.25, p = 0.02), lower education level (β = -0.21, p = 0.03), diabetes (β = -0.27, p = 0.01), and physical inactivity (β = -0.19, p = 0.04). 61% of the variation in HRQoL was explained by the regression model (adjusted R2 = 0.61). Conclusion: In CKD patients, comorbid conditions, socioeconomic position, and psychological well-being have a major influence on HRQoL. To improve quality of life, integrated care that addresses both clinical and psychosocial aspects is advised. Author’

• 1.   Hays R.D., Kallich J.D., Mapes D.L., Coons S.J., Carter W.B. Development of the Kidney Disease Quality of Life (KDQOL™) Instrument. Qual Life Res. 1994; 3(5): 329–38.
• 2.   Abdel-Kader K., Unruh M.L., Weisbord S.D. Symptom burden, depression, and quality of life in chronic and end-stage kidney disease. Clin J Am Soc Nephrol. 2009; 4(6): 1057–64.
• 3.   Finkelstein F.O. et al. Depression and anxiety in chronic kidney disease and end-stage renal disease: Review of epidemiology, diagnosis, and treatment. Kidney Int. 2009; 75(1): 36–45.
• 4.   WHO. Physical activity guidelines. Geneva: World Health Organization; 2020.
• 5.   Lopes A.A. et al. Health-related quality of life and associated outcomes among hemodialysis patients. Clin J Am Soc Nephrol. 2007; 2(4): 576– 86
• 6.   Abdel-Kader, K., Unruh, M.L., & Weisbord, S. D. (2009). Symptom burden, depression, and quality of life in chronic and end-stage kidney disease. Clinical Journal of the American Society of Nephrology, 4(6), 1057–1064. https://doi.org/10.2215/CJN.00430109
• 7.   Finkelstein, F.O., Wuerth, D., & Finkelstein, S. H. (2009). Depression and anxiety in chronic kidney disease and end-stage renal disease: Review of epidemiology, diagnosis, and treatment. Kidney International, 75(1), 36–45. https://doi.org/10.1038/ki.2008.500
• 8.   Hays, R.D., Kallich, J.D., Mapes, D.L., Coons, S.J., & Carter, W.B. (1994). Development of the Kidney Disease Quality of Life (KDQOL™) instrument. Quality of Life Research, 3(5), 329– 338. https://doi.org/10.1007/BF00451725
• 9.   Lopes, A.A., Bragg-Gresham, J.L., Goodkin, D. A., Fukuhara, S., Mapes, D.L., Young, E.W., & Held, P.J. (2007). Health-related quality of life and associated outcomes among hemodialysis patients of the Dialysis Outcomes and Practice Patterns Study (DOPPS). Clinical Journal of the American Society of Nephrology, 2(4), 576–586. https://doi.org/10.2215/CJN.00040107
• 10.   Tsai, Y.C., Tsai, J.C., Chen, S.C., Chiu, Y.W., Hwang, S.J., Hung, C.C., ... & Chen, H.C. (2010). Association of physical activity with cardiovascular and renal outcomes and quality of life in chronic kidney disease. PLoS ONE, 5(8), e12903. https://doi.org/10.1371/journal. pone.0012903
• 11.   World Health Organization. (2020). WHO guidelines on physical activity and sedentary behaviour. Geneva: World Health Organization. https://www.who.int/publications/i/ item/978924001512

Data Sharing Statement

Funding