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Indian Journal of Anesthesia and Analgesia

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A Comparative Study of Oral Gabapentin and Oral Clonidine as Preemptive Analgesia under Spinal Anesthesia for Abdomino-Pelvic Surgeries

Ankita Hajare , Ankita Hajare1 , Irfan A Waris2

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Indian Journal of Anesthesia and Analgesia 6(4):p 1299-1304, July-August 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6419.33

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Ankita Hajare, Irfan A Waris. A Comparative Study of Oral Gabapentin and oral Clonidine as Preemptive Analgesia under Spinal Anesthesia for Abdomino-Pelvic Surgeries. Indian J Anesth Analg. 2019;6(4):1299-1304.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Aim: To assess the effect of oral Gabapentin and oral Clonidine used as Preemptive analgesia to attenuate postoperative pain in patients undergoing elective Abdomino-Pelvic surgeries under Spinal Anesthesia. Objective: To assess postoperative analgesic benefit, their postoperative efficacy with respect to duration of analgesia and total postoperative requirement and side effects if any of both the groups. Material and Method: 60 patients of either sex of age between 18-65 years, ASA grade I & II, patient admitted to Khaja banda nawaz teaching and general hospital for elective abdominal surgeries under spinal anesthesia were included in the study. The patients were randomly allocated into two groups of 30 each, group G received Gabapentin 300 mg tablet orally 90 min before surgery, group C received clonidine 100 μg tablet orally 90 min before surgery. Duration of postoperative analgesia, Degree of postoperative pain (VAS score) and added rescue analgesia required in 24 hrs were recorded postoperatively. Result: Analysis revealed the postoperative analgesic efficacy of oral Gabapentin showed better pain tolerance compared to that of oral Clonidine. The Ramsay sedation score showed a significant sedative effect by Gabapentin than in Clonidine at 90 mins, haemodynamic parameters changes suggested Gabapentin to be haemodynamically stable than clonidine, Morphine consumption in 24 hrs was significantly high in Clonidine group with increased incidence of nausea and vomiting. Conclusion: Oral Gabapentin 300 mg given before 90 minutes as preemptive analgesia was more effective in reducing postoperative pain and morphine consumption, also providing better anxiolysis in patients undergoing abdomino-pelvic Surgeries under spinal anesthesia compared to Oral Clonidine 100 μg.

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Ankita Hajare, Irfan A Waris. A Comparative Study of Oral Gabapentin and oral Clonidine as Preemptive Analgesia under Spinal Anesthesia for Abdomino-Pelvic Surgeries. Indian J Anesth Analg. 2019;6(4):1299-1304.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6419.33

Keywords

Analgesia; Clonidine; Gabapentin.

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