Full Text (PDF)
Original Article

A Comparative Study of Hyperbaric 0.5% Levobupivacaine with Bupivacaine 0.5% for Spinal Anaesthesia in Elective Surgeries

Srinivas H.T, Girish B.K., Shwetha M Reddy, Archana K.N.

Author Information

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.



Indian Journal of Anesthesia and Analgesia 5(12):p 2013-2020, November 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.51218.8

How Cite This Article:

Girish B.K., Srinivas H.T., Shwetha M. Reddy et al. A Comparative Study of Hyperbaric 0.5% Levobupivacaine with Bupivacaine 0.5% for Spinal Anaesthesia in Elective Surgeries. Indian J Anesth Analg. 2018;5(12):2013­20.

Timeline

Received : October 11, 2018         Accepted : October 13, 2018          Published : October 30, 2018

Abstract

  Background: Subarachnoid block is popular and commonly used worldwide. The advantage of an awake patient, minimal drug cost and rapid patient turnover has made this the method of choice for many surgical procedures. Among the popular drugs used for subarachnoid block are bupivacaine and and its enantiomer Levobupivacaine. Objectives: A clinical study to compare the effect of spinal anaesthesia with 0.5% hyperbaric levobupivacaine and 0.5% hyperbaric bupivacaine in patients undergoing elective below umbilical surgeries. Materials and Methods: 60 patients of American Society of Anaesthesiologists physical status class1 and 2 patients with 18 to 70 years of age posted for elective lower limb surgeries under subarachnoid block technique were randomly assigned into 2 equal groups. Group L received intrathecal hyperbaric 0.5% levo bupivacaine [total 3.5ml], Isobaric levobupivacaine made hyperbaric by adding 0.5ml of 50% dextrose to 3ml of levobupivacaine, Group B received intrathecal 15mg hyperbaric 0.5% bupivacaine with 0.5ml of normal saline.[total 3.5ml]. Results: Group L and Group B had similar onset of sensory blockade. Group L had delayed onset of motor blockade, lesser degree of motor blockade and lesser quality of intraoperative anaesthesia, similar level of sensory and maximum upper spread of sensory blockade, time  taken for two segment regression time and duration of motor blockade but shorter duration of analgesia when compared to Group B. Conclusion: Hyperbaric 0.5% bupivacaine remains effective choice than hyperbaric 0.5% levobupivacaine for spinal anaesthesia in elective surgeries, But hyperbaric levobupivacaine is also a better option for shorter procedures and outpatient spinal anaesthesia.


References

  • 1.   Grist Wood RW. Cardiac and CNS toxicity of levobupivacaine: strengths of evidence for advantage over bupivacaine. Drug Saf 2002;25(3):153­63.
  • 2.   Europeans Medicines Agency. Chirocaine 1.25 mg/ ml solution for infusion: summary of product Girish B.K., Srinivas H.T., Shwetha M. Reddy et al. / A Comparative Study of Hyperbaric 0.5% Levobupivacaine with Bupivacaine 0.5% for Spinal Anaesthesia in Elective Surgeries2020 Indian Journal of Anesthesia and Analgesia / Volume 5 Number 12 / December 2018 characteristics [online]. Available from URL: http:// www.emc.medicines.org.uk/medicine/19678 [Accessed 2010 Mar 25].
  • 3.   Gulen Guler, Gokhancakir et al. A Comparison of Spinal Anesthesia with Levobupivacaine and Hyperbaric Bupivacaine for Cesarean Sections: A Randomized Trial. Open journal of anaesthesiology. 2012;2:84­89.
  • 4.   Luck JF, Fettes PDW, Wildsmith JAW. Spinal anaesthesia for elective surgery: a comparison of hyperbaric solutions of racemic bupivacaine, levobupivacaine, and ropivacaine. British journal of anaesthesia. 2008;101(5):705­10.
  • 5.   Fattorini F, Ricci Z, Rocco A, Romano R, Pascarella MA, Pinto G. Levobupivacaine versus racemic bupivacainefor spinal anaesthesia in orthopaedic majorsurgery. Minerva Anestesiol 2006;72:637–44.
  • 6.   Glaser C, et al. Levobupivacaine versus racemic bupivacaine for spinal anaesthesia. AnaesthAnalg. 2002;94:194­8.
  • 7.   Y. Lee, K. Muchhal and C. K. Chan. Levobupiva­ caine versus Racemic Bupivacaine in Spinal Anesthesia for Urological Surgery. Anaesthesia and Intensive Care, 2003;31(6):637­41.
  • 8.   H. Sen, T. Portuloglu et al., Comparison of intrathecal hyperbaric and isobaric levobupivacaine in urological surgery. Minerva anaesthesiologica 2010;76:24­28.
  • 9.   Bernards CM. Epidural and spinal anesthesia. In clinical anesthesia 6th edition.
  • 10.   Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC (eds). Phildelphia; Lippioncot Williams & Wilkins New York; 2010:927­950.
  • 11.   E.A. Alley, D.J. Kopacz, S.B. McDonald and S.S. Liu, Hyperbaric Spinal Levobupivacaine: A Comparison to Racemic Bupivacaine in Volunteers. Anesthesia& Anal­ gesia, 2002;94(1):188­93.

About this article


Cite this article

Girish B.K., Srinivas H.T., Shwetha M. Reddy et al. A Comparative Study of Hyperbaric 0.5% Levobupivacaine with Bupivacaine 0.5% for Spinal Anaesthesia in Elective Surgeries. Indian J Anesth Analg. 2018;5(12):2013­20.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.



Received Accepted Published
October 11, 2018 October 13, 2018 October 30, 2018

DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.51218.8

Keywords

Hyperbaric; Bupivacaine; Levobupivacaine; Subarachnoid Blockade.

Article Level Metrics

Last Updated

Friday 11 September 2026, 05:48:09 (IST)


9033

Accesses

34
803
00

Citations


NA
NA
NA

Download citation


Article Keywords


Keyword Highlighting

Highlight selected keywords in the article text.


Timeline


Received October 11, 2018
Accepted October 13, 2018
Published October 30, 2018

licence


Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.



Access this article



Share