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A Comparative Study between Thiopental Sodium and Etomidate on Hemodynamic Response in Adult Treated Hypertensives Scheduled for Elective Surgery

J Hymavathi , V Praveen Kumar , J Hymavathi

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Indian Journal of Anesthesia and Analgesia 7(1):p 143-149, January-February 2020. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7120.20

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V Praveen Kumar, J Hymavathi. A Comparative Study between Thiopental Sodium and Etomidate on Hemodynamic Response in Adult Treated Hypertensives Scheduled for Elective Surgery. Indian J Anesth Analg. 2020;7(1 Part -I):143–149.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Context: Ideal drugs used for anesthesia for induction should counter the response to stress at the same time not affecting the changes in the hemodynamics of the patient. This is required because induction is an important part in anesthesia.

Aim: To compare hemodynamic response to induction of anesthesia with thiopentone or etomidate in adult treated hypertensive patients. Settings and Design: Present hospital based comparative study was carried out at Adichunchanagiri Institute of Medical Sciences, BG Nagar, Bellur.

Methods: 60 adult treated hypertensive patients of either sex, aged between 29 and 61 years, belonging to ASA I and II who were randomly allotted to Two Groups of 30 each. Group T received 5 mg/kg of thiopentone sodium and Group E received Etomidate 0.3 mg/kg. Pulse rate, systolic, diastolic and mean arterial pressures both after premedication (level 0) and at every minute for five minutes (levels 1–5) postinduction with both drugs were recorded. Statistical Analysis: The data was analyzed using t-test for comparing mean values between Two Groups.

Results: SBP fell to 120 ± 28.8 from 131.70 ± 16.03 (level 0) in Group T and fell to 120.80 ± 20.05 from 131.23 ± 16.03 (level 0) in Group E. DBP had a slight fall to 77.73 ± 17.00 at 4 minutes in Group T. MAP fell from 94.52 ± 12.10 (level 0) to 91.72 ± 21.34 in Group T and fell from 96.96 ± 12.96 (level 0) to 90.37 ± 17.51 in Group E. Comparison of variations in heart rate, SBP, DBP and map from level 0 to postinduction recordings at 1–5 levels between Two Groups was insignificant (p > 0.05). Patients in both Groups did not have any side effects.

Conclusion: Both drugs are comparable in efficacy and safety. Thiopentone comparatively has better cost effectiveness and ease of availability.

 

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Cite this article

V Praveen Kumar, J Hymavathi. A Comparative Study between Thiopental Sodium and Etomidate on Hemodynamic Response in Adult Treated Hypertensives Scheduled for Elective Surgery. Indian J Anesth Analg. 2020;7(1 Part -I):143–149.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7120.20

Keywords

Thiopental sodium; Etomidate; Hemodynamic response; Hypertension; Surgery.

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