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Indian Journal of Anesthesia and Analgesia

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A Comparative Study between Ropivacaine with Dexmedetomidine and Ropivacaine with Fentanyl in Lower Abdominal and Lower Limb Surgeries for Postoperative Epidural Analgesia

Prabhavathi R., Associate Professor, Dept. of Anesthesiology, Narayana Medical College, Chinthareddypalem, Nellore, Andhra Pradesh 524003. , Prabhavathi R.* , Bhoopal Naik.V** , P. Narasimha Reddy*** , Samanth Reddy**** , . Sravanthi*****

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Indian Journal of Anesthesia and Analgesia 4(2):p 391-398, April - June 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.5

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Abstract

AIM: Clinical evaluation of efficacy of adding Dexmedetomidine and Fentanyl to Ropivacaine in lower abdominal and lower limb surgeries . Method: This was a randomized double blind study of postoperative epidural analgesia was done in 100 patients divided into 50 patients each, Group-A Patients received 15ml of 0.2% Ropivacaine + 1mcg/kg of Dexmedetomidine and Group-B Patients received 15ml of 0.2% of Ropivacaine + 1mcg/kg of Fentanyl and onset, duration of analgesia, sedation score, visual analogu scale(VAS) were assessed. Results: The onset of analgesia in Group A was 8.21min and in Group B it was 10.23 min, which is statistically significant (P<0.05). Duration of analgesia in Group A was 336 min when compared to Group B which was 260min (p<0.05). No. of Patients with Sedation score of grade 2 and 3 are more in Group-A than in Group-B. There was a significant difference of VAS score between the two groups at 15 minutes, 30mins, 45mins, 60mins, 120 min, 180 min, 240 min and 330mins post operatively (p value < 0.05) that the A group had lower VAS score then B group. Conclusion: Dexmedeto-midine as an adjuvant to Ropivacaine in epidural analgesia seems to be  a better alternatiec to Fentanyl, as it provides comparable stable hemodynamics, early onset of analgesia, prolonged post-op analgesia, and much better sedation levels.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.5

Keywords

Dexmedetomidine; Hemodynamics; Analgesia; Visual Analogue Scale.

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