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Indian Journal of Anesthesia and Analgesia

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A Comparative Study between Intrathecal Bupivacaine with Clonidine vs Bupivacaine with Neostigmine for Vaginal Hysterectomies: A Randomized Double Blinded Study

M. Santhi Sree, Associate Professor, Department of Anaesthesia, Siddhartha Medical college, Vijayawada, Andhra Pradesh 520008, India. , M. Santhi Sree1 , N. Krishna Veni2

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Indian Journal of Anesthesia and Analgesia 5(7):p 1210-1214, July 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5718.19

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Abstract

Introduction: Vaginal hysterectomy is the most common surgery done under spinal anaesthesia. The combination of local anaesthetics with adjuvants is getting more popular for better post-operative analgesia.

Aim: The purpose of our study is to evaluate and compare the addition of clonidine and neostigmine to intrathecal bupivacaine for prolongation of post-operative analgesia.

Materials & Methods: This was a prospective, randomized, controlled, double blind study carried out in patients undergoing vaginal hysterectomies. 50 patients of ASA grade I & II between 45-60years of age were assigned to 2 groups. Group BC: received 0.5ml of intrathecal clonidine (75g) along with 2.5ml of 0.5% Bupivacaine Group BN: received 0.5ml of intrathecal neostigmine(50g) along with 2.5ml of 0.5%bupivacaine.

Results: Sensory block onset, level of sensory block, duration of analgesia, motor block onset, duration of motor block, degree of motor block and recovery from motor block and incidence of side-effects are evaluated.

Conclusion: We concludefrom our study that intrathecal neostigmine 50g added to 12.5 mg hyperbaric bupivacaine significantly hastens the onset of sensory and motor block when compared to 75g clonidine and duration of analgesia is more prolonged with clonidine than neostigmine.

 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5718.19

Keywords

Neostigmine; Clonidine; Post-Operative Analgesia.

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