Indian Journal of Trauma and Emergency Pediatrics

Aim of this case report is to assess role of negative pressure wound therapy in scalds to faster healing. Clinical examination of the extent of the burn was done. Standard management (antibiotics, Intravenous fluids, analgesics. Dressings, regenerative therapies, scar management) of the burns was done along with that autologous bone marrow aspirate. Autologous bone marrow aspirate is effective in preventing abnormal scarring. Negative pressure wound therapy may be used to promote faster wound healing.

Duplication cysts are rare congenital anomalies of the gastrointestinal tract and the occurrence of multiple such cysts is an extremely rare occurrence. Autoimmune hemolytic anemia is an extremely unusual manifestation of these duplication cysts. Herein, we report a case with two duplication cysts (one cyst in the thorax; another in the abdomen) complicated with autoimmune hemolytic anemia. This patient was a five year-old-male child who presented with congestive cardiac failure due to severe anemia (which, on evaluation, was diagnosed as autoimmune hemolytic anemia). Imaging studies (chest radiograph and computed tomography) revealed duplication cysts in the chest and abdomen. Anemia flare-up was noted in the patient despite two months of prednisolone therapy (2 mg/kg/day) and two high dose intravenous methylprednisolone pulse therapy courses (30 mg/kg/day for 5 days each). The steroid refractory autoimmune hemolytic anemia responded to rituximab (375 mg/m2 body surface area/week for 4 weeks). Four months after tapering off the steroid therapy, the patient did not experience flare-up of the anemia. To the best of our knowledge, this is the youngest and first pediatric age group patient to be reported, with a possible association between gastrointestinal duplication cysts with autoimmune hemolytic anemia.

This research article review the key types of genetic research design, methodology involved and emerging and established finding in relation to child and childhood psychiatric disorders, and finally genetic factors seems especially important for autism and attention deficit hyperactivity disorder. (Thapar and McGuffin, 2008)1 Twin and adoption study design are now being used to examine gene environment interplay, the effects of environment risk factors co-morbidity phenotype definition and development change Liu et al (2006)11 The ways in which specific gene variant excert risk effects at cellular and biological system are proving to highly competitive (Moffitt et al, 2005).2 Finally, molecular genetic studies also high light the importance of gene environment interply, which seems to be especially important in depression and wide anti social behavior. Liu. et al)11, owen et al 2005)12 , Moffitt, et al, (2005)2