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Verapamil as an Adjunct to Local Anesthetic Solution for Supraclavicular Brachial Plexus Block

GS Mahishale , Deepa Allolli1 , GS Mahishale2 , Rajendra Kumar B3 , Nazeer Ahmed K4 , Mrudula M Watawe5 , Priyanka H6

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Indian Journal of Anesthesia and Analgesia 6(6):p 1925-1929, November-December 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6619.7

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Deepa Allolli, GS Mahishale, Rajendra Kumar B et al. Verapamil as an Adjunct to Local Anesthetic Solution for Supraclavicular Brachial Plexus Block. Indian J Anesth Analg. 2019;6(6 Part -I):1925-1929.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Introduction: Calcium permeability is reduced by local anesthetics, and calcium ions play an important role in opioid-receptor mediated analgesia. The aim of this study is to evaluate whether addition of verapamil into local anesthetic for brachial plexus block provide additional anesthetic and analgesic effects. Methodology: Sixty patients undergoing upper extremity surgery were randomized to either Group A (20 ml of 1% lignocaine, 20 ml of 0.25% bupivacaine, 1 ml normal saline) or Group B (20 ml of 1% lignocaine, 20 ml of 0.25% bupivacaine, 1 ml 2.5 mg verapamil). Results: Baseline characteristics like age, gender distribution and body weight were similar in both the study groups. Mean duration of sensory block was found to be significantly higher in the group of patients receiving verapamil (191 ± 45.59 minutes vs 163 ± 45.72 minutes; p value < 0.01). Rest of the parameters like mean time of onset of sensory and motor block, duration of motor block and duration of analgesia were similar in both the study groups. There was no difference in the proportions of hemodynamic complications like heart rate, systolic blood pressure and oxygen saturation among the patients in the two groups as well. Conclusions: Our results show that adding verapamil to brachial plexus block can prolong sensory block. However, no change in analgesic properties or hemodynamic changes was observed.

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Deepa Allolli, GS Mahishale, Rajendra Kumar B et al. Verapamil as an Adjunct to Local Anesthetic Solution for Supraclavicular Brachial Plexus Block. Indian J Anesth Analg. 2019;6(6 Part -I):1925-1929.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6619.7

Keywords

Brachial plexus block; Levobupivacaine; Verapamil.

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