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New Indian Journal of Surgery 3(3):p 185-185, July - September 2012. | DOI:
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The Neurotrophic Effect of Tacrolimus (FK506) on Pyramidal Cells of Brain Cortex Following Global Ischemic/Reperfusion in Wistar Rat
Ghazal Ansarian , Ghazal Ansarian , Zahra-Nadia Sharifi , Shabnam Movassaghi , Hamed Shafaroodi , Nooshin Panahi Khezri
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New Indian Journal of Surgery 3(3):p 185-185, July - September 2012. | DOI:
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Abstract
Cerebral ischemia is known as a major problem in the world. Transient global cerebral ischemia causes loss of pyramidal cells of brain cortex following global ischemic/reperfusion. Recently, using immunophilin ligands has been considered as a potential and appropriate strategy for neuroprotection. Since it was observed that tacrolimus (FK506), a useful immunosuppressant used in organ transplantation, provides neuroprotection and prevents neuronal damage,the importance of immunophilins in the development of neuroprotectors has emerged.
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