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The Effectiveness of FFP Transfusion on INR Values in Chronic Liver Patients with Deranged INR

Gireesh Kumar , Sona Kurian , Gireesh Kumar , Dhanasekharan BS , Naveen Mohan , Sreekrishnan TP , Arun Kumar , Bharath Prasad

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Indian Journal of Emergency Medicine 5(1):p 33-35, January-March 2019. | DOI: http://dx.doi.org/10.21088/ijem.2395.311X.5119.6

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Abstract

 Objective: To find the effectiveness of FFP transfusion on INR values in Chronic Liver Disease patient with deranged INR. The aim of this study is to find the usefulness of FFP transfusion before emergency invasive procedure in chronic liver disease patients with deranged INR in emergency department. Materials and Methods: This is a prospective observational study conducted in a total of 62 chronic liver disease patients with CHILD C grade with deranged INR who require emergency invasive procedure like central line insertion. Pre and post transfusional INR measured and mean improvement in INR calculated. Relationship between pre transfusional INR and improvement in INR per FFP was studied using Pearson correlation coefficient. Results: The mean improvement in INR was 0.55 (standard deviation 0.88). The correlation coefficient between pre and post transfusional INR was 0.50 and significance is 0.000. The linear relationship was noted between pre transfusional INR and improvement in INR per unit of FFP. Conclusion: FFP transfusion before emergency invasive procedure in chronic liver patients with deranged INR is effective in reducing INR values to some extend but not effective in normalisation of INR value.

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DOI: http://dx.doi.org/10.21088/ijem.2395.311X.5119.6

Keywords

Chronic Liver Disease; FFP; INR.

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