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Study of Immunodeftcieny Degree (CD 4 count) as a Predictor of Pulmonary Tuberculosis at a HIV Sentinel Surveillance Center, Ahmednagar

, Saili Jadhav1 , Sadhana Khaparde2 , Shubhada S. Avachat3

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Indian Journal of Communicable Diseases 5(1):p 19-24, January-June 2019. | DOI: DOI: http://dx.doi.org/10.21088/ijcd.2395.6631.5119.3

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Saili Jadhav, Sadhana Khaparde, Shubhada S. Avachat. Study of Immunodeftcieny Degree (CD 4 count) as a Predictor of Pulmonary Tuberculosis at a HIV Sentinel Surveillance Center, Ahmednagar. Indian J Comm Dis. 2019;5(1):19-24.

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Abstract

Diagnosing tuberculosis in Human Immunodeficiency Virus (HIV) infected person is a major public health challenge. An integral component of the World Health Organization (WHO) strategy for reducing the burden of HIV related TB disease is intensified case finding (ICF) for TB among HIV infected person. (Maher et al., 2005) (World Health Organization; 2004, Intrim policy). Aim: To study the changes/ variations in CD4 count of HIV positive patients with pulmonary tuberculosis. Study design: It was a retrospective, analytical study. Materials and methods: The study was conducted by collecting and assessing data of past 3 year of HIV positive individuals in civil hospital of Ahmednagar (HIV sentinel surveillance) with pulmonary tuberculosis fulfilling the inclusion and exclusion criteria. Data analysis: The collected data was compared amongst each other and descriptive statistics like mean, median, mode and proportion was used. Inferential statistics had application of student t test variably. Study place: The study was conducted in civil hospital of Ahmednagar (HIV sentinel surveillance) with permission from Civil surgeon (Dr. Sonawane) and Nodal officer of Anti Retroviral Treatment (ART) (Dr. Ingle). Results and Conclusion: Total patients in HIV Sentinel Surveillance Center in the year 2016, 2017, 2018 were 3062. Out of 3062 HIV positive patients, 1528 were females and 1531 were males and 4 where transgender. Maximum number of HIV positive patients where seen in the age group of 31-40. Amongst these 251 patients died on ART and 154 stopped treatment or transferred out. 285 patients out of the total were coinfective with tuberculosis infections. Amongst them 58 died whilst on ART. 1.81/1.4 is the male is to female ratio of the co-infected patients. 0 transgender patients were co-infected. The comparison between baseline CD4 to La-test CD4 was variable. It mainly depended on the age of the patient and how they reacted to the ART as individuals. AntiRetroviral Therapy helps in increasing the immunity of the patient, therefore helping in controlling the severity of pulmonary tuberculosis.

Keywords: Ahmednagar district; HIV sentinel surveillance; Tuberculosis; CD4 Cell Count; Co-infection; Human Immunodeficiency Virus (HIV); Acquired Immunodeficiency Syndrome (AIDS); Oppor- tunistic Infection.

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Saili Jadhav, Sadhana Khaparde, Shubhada S. Avachat. Study of Immunodeftcieny Degree (CD 4 count) as a Predictor of Pulmonary Tuberculosis at a HIV Sentinel Surveillance Center, Ahmednagar. Indian J Comm Dis. 2019;5(1):19-24.

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DOI: DOI: http://dx.doi.org/10.21088/ijcd.2395.6631.5119.3

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