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Serum Procalcitonin As Biomarker for Early Diagnosis of Sepsis

Ravi Shankar V, Associate Professor, Department of Emergency and Critical Care Medicine, Narayana Medical College and Hospital, Chinthareddypalem, Nellore-524003, India , Pranay Krishna P1 , Ravi Sankar V2 , Raghu Kondle3 , B Dhiram Showri4 , A Shiva Kumar5 , Siri Priya6

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Indian Journal of Emergency Medicine 6(3):p 159-172, July – September 2020. | DOI: http://dx.doi.org/10.21088/ijem.2395.311X.6320.4

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Pranay Krishna P, Ravi Sankar V, Raghu Kondle, Serum Procalcitonin As Biomarker for Early Diagnosis of Sepsis. Indian J
Emerg Med 2020;6(3):159–173
 

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Aim: study designed to analyse the Procalcitonin for early detection of
sepsis. Method: procalcitonin, blood, urine culture, and ultrasound were
performed and patients were categorized into groups based on PCT levels.
Results: 40% had respiratory infections, 30% showed urinary tract infections,6% gastrointestinal tract infections, 4% soft tissue infections and 6% werewith other types of infections. 84% cases with sepsis and 16% cases with nosepsis. Sepsis was observed in 40 % and septic shock in 44% cases. 36% caseswere died. Acute febrile illness observed in 6 (12%), ARDS and pyelonephritis with sepsis recorded in 4(8%). vasoactive support (VA) was given to 28
patients. 33.3% sepsis cases more than 10ng/ml procalcitonin was observed while none of the cases with no sepsis showed this level. 9.5% and 57.1% patients with sepsis, the procalcitonin level was below 2ng/ml and 2-10ng/ ml respectively. The mean procalcitonin in survivors was 5.47±3.02 ng/mlwhile it is 10.84± 5.66 ng/ml in non survivors. The mean lactate in survivors was 6.68± 2.04 and it is 8.17± 2.02 in non survivors. The mean procalcitonin level was 3.23 ng/ml in APACHE II (Score<10), 7.50 ng/ml in APACHE II (Score10-20) and increased to 10.29 ng/ml in APACHE II (Score>20). The mean procalcitonin level was 4.14 ng/ml in SOFA (Score<10), 9.57 ng/ml in SOFA (Score10-20) and increased to 13.75 ng/ml in SOFA (Score>20).
Conclusion: present study showed that procalcitonin is a useful marker inearly diagnosis of septic shock, help in management.


Keywords: Sepsis, Serum Procalcitonin, APACHE II, Ventillator Support

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Cite this article

Pranay Krishna P, Ravi Sankar V, Raghu Kondle, Serum Procalcitonin As Biomarker for Early Diagnosis of Sepsis. Indian J
Emerg Med 2020;6(3):159–173
 

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DOI: http://dx.doi.org/10.21088/ijem.2395.311X.6320.4

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