Ravi Kumar Chittoria Professor & Head, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Nishad K. Senior Resident, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Neljo Thomas Senior Resident, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Barath Kumar Singh Senior Resident, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Jacob Antony Chakiath Senior Resident, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Address for correspondence: Ravi Kumar Chittoria, Professor & Head, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India E-mail: drchittoria@yahoo.com
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Nishad K., Neljo Thomas et al./Role of Topical Minoxidil in Latissimusdorsi Flap Necrosis: Our Experience/International Physiology.2023;11(1):17–20.
Timeline
Received : December 13, 2022
Accepted : January 15, 2023
Published : April 27, 2023
Abstract
The purpose of this study was to determine the effectiveness of topically applied minoxidil in the pharmacological delay phenomenon. There are various types of delay including surgical delay, pharmacological delay. We have used topical minoxidil application on latissimusdorsi flap reconstruction for a patient who had undergone neoadjuvant chemoradiation. We have found that topical minoxidil can be used to prevent flap necrosis in such conditions.
References
1. Kronowitz SJ. Current status of implant-based breast reconstruction in patients receiving postmastectomy radiation therapy. Plast Reconstr Surg. 2012;130(4):513e–523e.
2. Kronowitz SJ. Current status of autologous tissue-based breast reconstruction in patients receiving postmastectomy radiation therapy. Plast Reconstr Surg. 2012;130(2):282–92.
3. Jagsi R, Jiang J, Momoh AO, Alderman A, Giordano SH, Buchholz TA, et al. Complications after mastectomy and immediate breast reconstruction for breast cancer: a claims-based analysis. Ann Surg. 2016;263(2):219–27.
4. Krueger EA, Wilkins EG, Strawderman M, Cederna P, Goldfarb S, Vicini FA, et al. Complications and patient satisfaction following expander/implant breast reconstruction with and without radiotherapy. Int J Radiat Oncol Biol Phys. 2001;49(3):713–21.
5. Contant CM, van Geel AN, van der Holt B, van der Bongard HJ, Wai RT, Wiggers T. Morbidity of immediate breast reconstruction (IBR) after mastectomy by a subpectorally placed silicone prosthesis: the adverse effect of radiotherapy. Eur J Surg Oncol. 2000;26(4):344–50.
6. Tallet AV, Salem N, Moutardier V, Ananian P, Braud AC, Zaffaroni M, et al. Radiotherapy and immediate two-stage breast reconstruction with a tissue expander and implant: complications and esthetic results. Int J Radiat Oncol Biol Phys. 2003;57(1):136–42.
7. Ascherman JA, Hanasono MM, Newman MI, Hughes DB. Implant reconstruction in breast cancer patients treated with radiation therapy. Plast Reconstr Surg. 2006;117(2):359–65.
8. Headington JT. Hair follicle biology and topical minoxidil: possible mechanisms of action. Dermatologica. 1987;175 Suppl 2:19–22.
9. Smorlesi C, Caldarella A, Caramelli L, Di Lollo S, Moroni F. Topically applied minoxidil may cause fetal malformation: a case report. Birth Defects Res A Clin Mol Teratol. 2003;67(12):997–1001.
10. DeVillez RL. The therapeutic use of topical minoxidil. Dermatol Clin. 1990;8(2):367–75.
11. Meisheri KD, Cipkus LA, Taylor CJ. Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability. J Pharmacol Exp Ther. 1988;245(3):751–60.
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
Whether all authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
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Cite this article
Nishad K., Neljo Thomas et al./Role of Topical Minoxidil in Latissimusdorsi Flap Necrosis: Our Experience/International Physiology.2023;11(1):17–20.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.