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Role of the Mini-Cog in Early Detection of Cognitive Impairment in Diabetes Mellitus: A Cross-sectional Study

Suman Kumar Kotwal, Shalija Kotwal, Monika Jaithal

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Indian Journal of Medical and Health Sciences 13(1):p 7-10, Jan - June 2026. | DOI: 10.21088/ijmhs.2347.9981.13126.1

How Cite This Article:

Suman Kumar Kotwal, Shalija Kotwal, Monika Jaithal. Role of the Mini-Cog in Early Detection of Cognitive Impairment in Diabetes Mellitus. A Cross-Sectional Study. Jr. Med. & Health Sci. 2026; 13(1): 07–10.

Timeline

Received : July 10, 2025         Accepted : October 22, 2025          Published : June 30, 2026

Abstract

Objective: Chronic hyperglycemia will result in many complications and patients living with diabetes are at increased risk of mild cognitive impairment (MCI) and dementia. There are basket of tests available for diagnosis of cognitive impairment, but all of them are time consuming. Minicog is simple and easy to perform and can be completed in three minutes. Early detection of MCI in patients with diabetes mellitus will help in delaying progression of cognitive decline. Methods: we enrolled 150 patients living with diabetes in our study. Minicog test was used for screening of MCI. Those having score of 3or 4 were considered to have MCI. Results: a total of 36.7% of patients had mild cognitive impairment. MCI was seen in 19% of women and 17.3% of men. Hba1c was negatively correlated with MCI. Conclusion: Minicog is a brief, simple and less time-consuming screening tool and is immensely helpful for quick screening of cognitive impairment.


References

  • 1.   D., Shaw J.E., Magliano D.J. The burden and risks of emerging complications of diabetes mellitus. Nat Rev Endocrinol. 2022; 18:525–39.
  • 2.   Banday M.Z., Sameer A.S., Nissar S. Pathophysiology of diabetes: an overview. Avicenna J Med. 2020; 10: 174–88.
  • 3.   Verdile G., Keane K.N., Cruzat V.F., et al. Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease. Mediators Inflamm. 2015; 2015: 105828.
  • 4.   Zilliox L.A., Chadrasekaran K., Kwan J.Y., et al. Diabetes and cognitive impairment. Curr Diab Rep. 2016; 16:87.
  • 5.   Petersen R.C. (2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256: 183–194. Suman Kumar Kotwal, Shalija Kotwal, Monika Jaithal. Role of the Mini-Cog in Early Detection of Cognitive Impairment in Diabetes Mellitus. A Cross-Sectional Study.10 Indian Journal of Medical and Health Sciences IJMHS / Volume 13, Number 1 / January – June 2026
  • 6.   Tschanz J.T., Welsh-Bohmer K.A., Lyketsos C.G., Corcoran C., Green R.C., Hayden K., et al. Conversion to dementia from mild cognitive disorder: the Cache County Study. Neurology. 2006 Jul 25; 67(2): 229-34.
  • 7.   Davis W.A., Zilkens R.R., Starkstein S.E., Davis T.M., Bruce D.G. Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I. Diabetologia. 2017 Jan; 60(1): 89-97.
  • 8.   Biessels G.J., Strachan M.W., Visseren F.L., Kappelle L.J., Whitmer R.A. Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions. Lancet Diabetes Endocrinol. 2014 Mar; 2(3): 246-55.
  • 9.   Sachdev P.S., Lipnicki D.M., Kochan N.A., Crawford J.D., Thalamuthu A., Andrews G, et al. The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. PLoS One. 2015; 10(11): e0142388.
  • 10.   Lopez O.L, Kuller L.H., Becker J.T., Dulberg C., Sweet R.A., Gach H.M., et al. Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study. Arch Neurol. 2007 Mar; 64(3): 416-20.
  • 11.   Cooper C., Sommerlad A., Lyketsos C.G., Livingston G. Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis. Am J Psychiatry. 2015 Apr; 172(4): 323-34.
  • 12.   Albert M.S., DeKosky S.T., Dickson D., Dubois B., Feldman H.H., Fox N.C., et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011 May; 7(3): 270-9.
  • 13.   Livingston G., Sommerlad A., Orgeta V., Costafreda S.G., Huntley J., Ames D., et al. Dementia prevention, intervention, and care. Lancet. 2017 Dec 16; 390(10113): 2673-734.
  • 14.   Lalithambika C.V., Arun C.S., Saraswathy L.A., Bhaskaran R. Cognitive Impairment and its Association with Glycemic Control in Type 2 Diabetes Mellitus Patients. Indian J Endocrinol Metab. 2019; 23(3): 353-6.
  • 15.   Varghese S.M., Joy N., John A.M., George G., Chandy G.M., Benjamin A.I. Sweet Memories or Not? A Comparative Study on Cognitive Impairment in Diabetes Mellitus. Front Public Health. 2022; 10: 822062. 16. Liu S., Lu Y., Cai X., Cong R., Li J., Jiang H., et al. Glycemic Control is Related to Cognitive Dysfunction in Elderly People with Type 2 Diabetes Mellitus in a Rural Chinese Population. Curr Alzheimer Res. 2019; 16(10): 950-62.
  • 17.   Palta P., Carlson M.C., Crum R.M., Colantuoni E., Sharrett A.R., Yasar S, et al. Diabetes and Cognitive Decline in Older Adults: The Ginkgo Evaluation of Memory Study. J Gerontol A Biol Sci Med Sci. 2017 Dec 12; 73(1): 123-30.
  • 18.   West R.K., Ravona-Springer R., Schmeidler J., Leroith D., Koifman K., Guerrero Berroa E. et al (2014) The association of duration of type 2 diabetes with cognitive performance is modulated by long-term glycemic control. Am J Geriatr Psychiatry 22(10): 1055–1059.
  • 19.   Rawlings A.M., Sharrett A.R., Schneider A.L., Coresh J., Albert M., Couper D, et al. Diabetes in midlife and cognitive change over
  • 21.   Cukierman-Yaffe T., Gerstein H.C., Williamson J.D., Lazar R.M., Lovato L., Miller M.E., et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care. 2009 Feb; 32(2): 221-6.
  • 22.   Avadhani R., Fowler K., Barbato C., Thomas S., Wong W., Paul C., et al. Glycemia and cognitive function in metabolic syndrome and coronary heart disease. Am J Med. 2015 Jan; 128(1): 46-55.
  • 23.   Wium-Andersen I.K., Rungby J., Jørgensen M.B., Sandbæk A., Osler M., Wium-Andersen M.K. Risk of dementia and cognitive dysfunction in individuals with diabetes or elevated blood glucose. Epidemiol Psychiatr Sci. 2019 Aug 28; 29: e43.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.


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Cite this article

Suman Kumar Kotwal, Shalija Kotwal, Monika Jaithal. Role of the Mini-Cog in Early Detection of Cognitive Impairment in Diabetes Mellitus. A Cross-Sectional Study. Jr. Med. & Health Sci. 2026; 13(1): 07–10.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


Received Accepted Published
July 10, 2025 October 22, 2025 June 30, 2026

DOI: 10.21088/ijmhs.2347.9981.13126.1

Keywords

Cognitive impairmentDementiaScreeningMinicog

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Received July 10, 2025
Accepted October 22, 2025
Published June 30, 2026

licence


Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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