Ravi Kumar Chittoria Professor and Associate Dean (Academic), Head of IT Wing and Telemedicine, Department of Plastic Surgery and Telemedicine, JIPMER, Puducherry 605006, India
Preethee U. Department of Plastic Surgery and Telemedicine, JIPMER, Puducherry 605006, India
Amrutha J.S. Department of Plastic Surgery and Telemedicine, JIPMER, Puducherry 605006, India
Sriram V.S. Department of Plastic Surgery and Telemedicine, JIPMER, Puducherry 605006, India
Address for correspondence: Ravi Kumar Chittoria, Professor and Associate Dean (Academic), Head of IT Wing and Telemedicine, Department of Plastic Surgery and Telemedicine, JIPMER, Puducherry 605006, India E-mail: drchittoria@yahoo.com
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Preethee U, Chittoria RK, Amrutha JS, Sriram VS. Role of autologous platelet rich plasma in uptake of split skin graft site. RFP J Dermatol. 2025;10(1):7-10.
Timeline
Received : April 25, 2025
Accepted : May 12, 2025
Published : June 30, 2025
Abstract
Skin grafting is a time-honored surgical technique that has been widely utilized for wound coverage and reconstruction. Depending on the clinical scenario and the requirements of the defect, skin grafts can be classified into different types, such as partial-thickness and full-thickness grafts, based on the amount of dermis included along with the epidermis. Despite being a well-established procedure, several factors can influence the success of graft uptake, including graft immobility, wound bed nutrition, and prevention of infection. Various techniques and adjuncts have been developed over time to improve graft take rates and overall healing outcomes. In this article, we report a case of post-burn raw area successfully covered using a split-thickness skin graft (SSG). The graft take was further enhanced by the application of autologous platelet-rich plasma (APRP), which acted as a biological adhesive and promoted early healing through the release of growth factors.
References
1. Alves R., Grimalt R. Randomized placebo controlled, double-blind, half-head study toassess theef cacyof platelet-richplasma on the treatment of androgenetic alopecia. Dermatol Surg. 2016; 42: 491–7.
2. Andia I., Abate M. Platelet-rich plasma: underlying biology and clinical correlates. Regen Med. 2013; 8: 645–58.
3. Thimmanahalli G., Kumar M. Ef cacy of autologous platelet rich plasma over conventional mechanical xation methods in split thickness skin grafting. Int Surg J. 2018; 6: 108.
4. Schade V.L., Roukis T.S. Use of platelet-rich plasma with split-thickness skin grafts in the high-risk patient. Foot Ankle Spec. 2008; 1: 155 9.
5. Sánchez-González D.J., Méndez-Bolaina E., Trejo Bahena N.I. Platelet-rich plasma peptides: Key for regeneration. Int J Pept. 2012; 2012: 532519. doi: 10.1155/2012/532519. Epub 2012 Feb 22.
6. Anitua E., Andia I., Ardanza B., Nurden P., Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration Thromb Haemost 2004; 91: 4-15.
7. Salazar-Álvarez A.E., Riera-del-Moral L.F., García-Arranz M., Alvarez-García J, Concepción-Rodriguez N.A., Riera-de-Cubas L. Use of platelet-rich plasma in the healing of chronic ulcers of the lower extremity. Actas Dermosifiliogr. 2014 Jul-Aug; 105(6): 597-604.
8. Actas Dermosifiliogr 2014; 105: 597-604. Picard F., Hersant B., Bosc R., Meningaud JP: Should we use platelet-rich plasma as an adjunct therapy to treat “acute wounds”, “burns”, and “laser therapies”: A review and a proposal of a quality criteria checklist for further studies. Wound Repair Regen 2015; 23: 163-170.
9. Gibran N., Luterman A., Herndon D., Lozano D., Greenhalgh D.G., Grubbs L, et al. Comparison of fibrin sealant and staples for attaching split thickness autologous sheet grafts in patients with deep partial- or fullthickness burn wounds: a phase 1/2 clinical study. J Burn Care Res. 2007; 28: 401–8. 10.
10. Puttirutvong P. Meshed skin graft versus split thickness skin graft in diabetic ulcer coverage. J Med Assoc Thai. 2004; 87: 66–72.
11. Vijayaraghavan N., Mohapatra D.P., Friji M.T., Arjun A., Bibilash B.S., Pandey S., et al. Role of autologous platelet rich plasma (APRP) in wound healing. J Soc Wound Care Res. 2014; 7: 23–8.
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All authors contributed significantly to the work and approve its publication
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Cite this article
Preethee U, Chittoria RK, Amrutha JS, Sriram VS. Role of autologous platelet rich plasma in uptake of split skin graft site. RFP J Dermatol. 2025;10(1):7-10.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator