Abstract

Normal wound healing is a complex process which involves combination of diverse immunological and biological process.Lipoaspirate is a remarkable source of stem cells. Adult stem cells are easily isolated from a section of whole fat or lipoaspirate for application to burn wound to improve healing.In this study we used autologous lipoaspirate in a paediatric patient with burn wounds to face.
 

• 1.   Broughton G., Janis J.E., Attinger C.E. Wound healing: an overview. PlastReconstrSurg 2006; 117: 1e-S-32e-S
• 2.   Ceresa C., Borrone A., Fracchia L., Rinaldi M., Marchetti A., Tremolada C., Bosetti M. Lipoaspirate Shows In Vitro Potential for Wound Healing. Pharmaceutics. 2022 Feb 19;14(2):447.
• 3.   Strioga M., Viswanathan S., Darinskas A. et al. Same or not the same? Comparison of adipose tissue-derived versus bone marrow derived mesenchymal stem and stromal cells. Stem Cells Dev 2012; 21: 2724-52.
• 4.   Rigotti G., Marchi A., Galiè M. et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. PlastReconstrSurg 2007 Apr 15; 119(5):1409-22
• 5.   Schultz G., Sibbald G., Falanga V. et al. Wound bed preparation: a systematic approach to wound management. Wound Regen 2003; 11: 1-28 Repair
• 6.   Park B.S., Jang K.A., Sung J.H. et al. Adiposederived stem cells and their secretory factors as a promising therapy for aging. DermatolSurg 2008; 34(10):1323-6 skin
• 7.   Schachinger V., Erbs S, Elsässer A. et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006;355(12):1210-21
• 8.   Schachinger V., Erbs S., Elsässer A. et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: Heart (2006;27(23):2775-83
• 9.   Kim W.S., Park B.S., Sung J.H. et al. Wound healing effect of adipose-derived stem cells; a critical role of secretory factors on human dermal fibroblasts. J DermatolSci 2007;48(1):15-24
• 10.   Altman A.M., Yan Y., Matthias N et al. IFATS Series: Human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model. Stem Cells 2008;27(1):250-8
• 11.   Gregory C.A., Prockop DJ, Spees JL. Nonhematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Exp Cell Res 2005; 306(2):330-5
• 12.   Izadpanah R., Trygg C, Patel B. et al. Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 2006;99(5):1285-97
• 13.   Kim W.S., Park BS, Kim H.K. et al. Evidence supporting antioxidant action of adiposederived stem cells: protection of human dermal fibroblasts from oxidative stress. / DermatolSci 2008;49(2):133-42
• 14.   Kern S., Eichler H., Stoeve J et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006; 24(5):1294-301
• 15.   Liu T.M., Martina M, Hutmacher DW et al. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 2007;25(3):750-60
• 16.   Nambu M., Kishimoto S, Nakamura S et al. Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix. Ann PlastSurg 2009; 62(3):317-21
• 17.   Park C.H., Lee MJ, Kim J.P. et al. Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A. Photochem Photobiol 2006; 82(2):574-8

Data Sharing Statement

Funding