Home > Journals > Indian Journal of Maternal-Fetal & Neonatal Medicine

Indian Journal of Maternal-Fetal & Neonatal Medicine

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Red Cell Distribution Width to Platelet Ratio (RPR) - A Predictive Index of Ductal Closure in Preterm Neonates

Aswathy Rajan , Sahana Panambur1 , Aswathy Rajan2 , Prem Alva3 , Ashvij Shriyan4 , Santosh T Soans5

Author Information

Licence:



Indian Journal of Maternal-Fetal & Neonatal Medicine 6(1):p 23-28, Jan-June 2019. | DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.6119.5

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Introduction: Inflammatory processes have been proposed to have a role in maintaining the patency of Ductus Arteriosus. Red cell distribution width (RDW) levels escalate in the presence of inflammation. Our aim was to evaluate the role of red cell distribution width to platelet ratio (RPR) in predicting the closure of hemodynamically significant patent ductus arteriosus (hsPDA) in response to paracetamol therapy in preterm neonates. Methods: A prospective comparative study was conducted on preterm neonates less than 37 weeks of gestation diagnosed with hsPDA after obtaining Institutional ethical clearance and detailed informed consent from the parents. All the neonates were treated with oral paracetamol for 3 days and then reassessed for closure of PDA. RDW and platelet counts were analyzed within 24 hours of life and RPR was then calculated. Preterms with sepsis, anemia, asphyxia, major congenital malformations were excluded from the study. Results: 108 preterm neonates were admitted to the NICU during the study period, of which 50 neonates were included in the study. Ductus closed in 28 preterms following treatment by day 3. Mean RPR was found to be lower in the neonates in which the ductus closed by day 3. An RPR cut off of 0.12 having AUC of 0.769 had sensitivity of 68% and specificity of 86% with PPV and NPV of 79% and 77% respectively for the prediction of Ductus Arteriosus closure. Conclusion: Our study shows that RPR can be used as a simple and effective screening tool in foreseeing the successful closure of hsPDA with pharmacotherapy.

Keywords: Ductus Arteriosus; Ductal patency; Paracetamol; Inflammation.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.6119.5

Keywords


Article Level Metrics

Last Updated

Thursday 30 July 2026, 08:02:49 (IST)

1009

Accesses

3
175
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share