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Practical Aspect of Clozapine

Kankana Chakraborty, M.Sc. nursing Trainee, LGB Regional Institute of Mental Health, Tezpur 784001, Assam, India , Anjali Sancha1 , Kankana Chakraborty2

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International Journal of Practical Nursing 10(3):p 85-90, October - December 2022. | DOI: http://dx.doi.org/10.21088 ijpn.2347.7083.1032.2

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Anjali Sancha, Kankana Chakraborty/Practical Aspect of Clozapine/ Int J Practical Nurs. 2022; 10(3):85–90.
 

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Abstract

Clozapine is an atypical antipsychotic which is considered a gold standard in treatment for treatment-resistant schizophrenia. This drug is acting on multiple receptors like dopaminergic receptors, serotonergic receptors, adrenergic receptors, and muscarinic receptors. The action on dopaminergic and serotonergic receptors alleviates the positive and negative symptoms of schizophrenia but action on some other receptors explains its side effects. Though it is an outstanding drug in treatment-resistant schizophrenia, treatment-resistant mood disorder, co-morbid use of alcohol and other substances in schizophrenia, hostility, and suicidality of the patient with schizophrenia, due to its severe side effects among which some are fatal, it is of having limited use. Before starting the therapy, a proper history should be taken, a thorough physical examination and a review of the investigation to be done to get the baseline of the specific patient. During the therapy, the patient should be frequently checked for changes in different parameters like vital signs, absolute neutrophil counts, BMI, biological functions, etc by using a clozapine assessment checklist. A proper assessment will help to prevent the worsening of the side effects. If any adverse effect is observed, then symptomatic management is required.

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Anjali Sancha, Kankana Chakraborty/Practical Aspect of Clozapine/ Int J Practical Nurs. 2022; 10(3):85–90.
 

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DOI: http://dx.doi.org/10.21088 ijpn.2347.7083.1032.2

Keywords

Clozapine; Antipsychotic; Schizophrenia; Dopamine; Side-effect; Nursing Considerations; Treatment Regime; Assessment; Mood Disorders.

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