Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Nalbuphine versus Dexmeditomedine Effect on Hemodynamic Stress Response During Intubation

Mary Mammen , Mary Mammen 1 , Sreekumar MR 2

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 8(6):p 577-582, Nov-Dec 2021. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.8621.84

How Cite This Article:

Mary Mammen, Sreekumar MR/Nalbuphine versus Dexmeditomedine effect on Hemodynamic Stress Response
during Intubation/Indian J Anesth Analg. 2021; 8(6): 577-582.
 

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Aims: Sympathetic system gets stimulated ondirect laryngoscopy and intubationand catecholamines are released. This response though of short duration, is hazardous to compromised subjects with brain and cardiac dysfunction. Vagus nerve also can be stimulated during laryngoscopy and intubation.

Ourstudy is to find out the effects of Nalbuphine Hcl 5mgm and Dexmedetomidine 25mgm on hemodynamic variables SBP, DBP, MAP and HR at the time of laryngoscopy and intubation. Study was carried out in Pushpagiri Institute of Medical Sciences. Consecutive sampling technique was used to select study population.

Methodology: We selected 100 subjects, ASA1 and 2, were randomly grouped into 2 groups of 50 each. All our subjects received 500ml crystalloid solution. Allsubjects were induced on Propofol and intubated on succinylcholine. The stress response was assessed by observing hemodynamic variables SBP, DBP, MAP and HR.

Statistical Analysis: Data was digitized and analyzed using SPSS22.0. Independent sample test was used to assess the difference in parameters. Data was stratified on the basis of age and weight of 2 groups. P-value of less than 0.05 was considered statistically significant.

Conclusions: Dexmedetomidine influences HR and the effect is more as age advances. In subjects heavier than 80kg, mean HR was higher. The effect of Dexmedetomidine on heart rate was statistically significant at a P value less than 0.05. Nalbuphine, according to studies, increases BP and HR. In our study, this rise in MAP was observed in subjects heavier than 70kg. But this finding was not statistically significant.

References

No records found.


About this article

Cite this article

Mary Mammen, Sreekumar MR/Nalbuphine versus Dexmeditomedine effect on Hemodynamic Stress Response
during Intubation/Indian J Anesth Analg. 2021; 8(6): 577-582.
 

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.8621.84

Keywords

Nalbuphine Hcl; Dexmedetomidine; Laryngoscopy; Intubation stress.

Article Level Metrics

Last Updated

Saturday 28 February 2026, 11:26:35 (IST)

1389

Accesses

0
245
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share