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Methylene Blue Dye for Sentinel Lymph Node Biopsy in Breast Cancer: Our Experience

Veena K.L. Karanth, Associate Professor, Department of General Surgery, Kasturba Medical College and Hospital, Manipal Academy of Higher Education, Madhav Nagar, Manipal, Karnataka 576104, India. , Satya Vijay Chigurupati1 , Veena K.L. Karanth2

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New Indian Journal of Surgery 9(6):p 760-763, Nov-Dec 2018. | DOI: DOI: https://dx.doi.org/10.21088/nijs.0976.4747.9618.13

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Abstract

  Context: Evaluation of sentinel lymph node is essential in deciding on need for axillary clearance in patients with breast cancer. We evaluate the role of methylene blue dye in identifying sentinel lymph node in our institution. Aims: To evaluate the use of methylene blue dye to detect axillary lymph node involvement in breast carcinoma. Settings and Design: Prospective interventional study. Methods and Material: Women with node negative, biopsy proven breast carcinoma scheduled for modified radical mastectomy or breast conservative surgery were selected. Consent was taken. Five ml of 2% methylene blue dye was injected to the lateral aspect of tumor and massaged for five minutes. Axillary dissection was done. Lymph nodes stained blue and unstained were collected and examined separately for tumor involvement. Patient was examined postoperatively to evaluate for any adverse reactions. Statistical analysis used: Using Chi-square test- Fisher’s Exact Test. Results: Our study showed that the probability of sentinel node representing axillary status was significant (p value - 0.022). Sentinel and nonsentinel histology were in agreement in 80% cases. Conclusions: Methylene blue dye is an effective and safe blue dye for sentinel lymph node biopsy. 

Keywords: Methylene Blue Dye; Breast Cancer; Sentinel Lymph Node.

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DOI: DOI: https://dx.doi.org/10.21088/nijs.0976.4747.9618.13

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