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Case Report

Melioidosis with Involvement of CNS: A Case Report in Northeast India

Vishnu M., Rigen Jyoti Kalita, Tandra Biswas

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Indian Journal of Emergency Medicine 11(1):p 59-62, Jan -April 2025. | DOI: https://doi.org/10.21088/ijem.2395.311X.11125.9

How Cite This Article:

Vishnu M., Rigen Jyoti Kalita, Tandra Biswas. Melioidosis with Involvement of CNS: A Case Report in Northeast India. Ind J Emerg Med. 2025; 11(1): 59-62.

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Received : November 15, 2024         Accepted : December 27, 2024          Published : March 30, 2025

Abstract

Melioidosis is a rare and debilitating bacterial infection, continuing to pose a significant threat to public health in endemic regions. Caused by Burkholderia pseudo mallei, which is a widely distributed environmental saprophyte found in stagnant water and soil. This versatile pathogen can manifest in a wide range of clinical presentation often leading to delayed diagnosis and potentially fatal outcomes. Patient was 41 year old male from urban part of north east India, presented to emergency with complaints of fever, headache, progressive left sided cheek swelling which extends upto left periorbital region associated with confusion. MRI brain showed left temporal lobe abscesses with blood cultures showing growth of Burkholderia pseudomallei. Despite of diagnosis and treatment patient succumbed. This case study emphasizes the importance of early recognition, prompt diagnosis, and appropriate treatment in managing meliodosis with cerebral involvement.


References

  • 1.   Wiersinga W.J., Virk H.S., Torres A.G., Currie B.J., Peacock S.J., Dance DAB, Limmathurotsakul D. Melioidosis. Nat Rev Dis Primers. 2018 Feb 1; 4: 17107. doi: 10.1038/ nrdp.2017.107. PMID: 29388572; PMCID: PMC6456913. Limmathurotsakul, D.; Golding, N.; Dance, D.A.; Messina, J.P.; Pigott, D.M.; Moyes, C.L.; Rolim, D.B.; Bertherat, E.; Day, N.P.; Peacock, S.J.; et al. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat. Microbiol. 2016.
  • 2.   Limmathurotsakul D., Golding N., Dance D.A., Messina J.P., Pigott D.M., Moyes C.L., Rolim D.B., Bertherat E., Day N.P., Peacock S.J., Hay S.I. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol. 2016 Jan 11; 1: 15008. doi: 10.1038/nmicrobiol.2015.8. PMID: 27571754.
  • 3.   Limmathurotsakul D., Peacock S.J. Melioidosis: a clinical overview. Br Med Bull. 2011; 99: 125- 39. doi: 10.1093/bmb/ldr007. Epub 2011 May 9. PMID: 21558159
  • 4.   Datta D., Sekar A., Patnaik A., Mohanty S. A Case-Based Review of Management of CNS Melioidosis. Asian J Neurosurg. 2023 Dec 29; 18(4): 836-838. doi: 10.1055/s-0043-1776736. PMID: 38161600; PMCID: PMC10756835.
  • 5.   Lipsitz R., Garges S., Aurigemma R., Baccam P., Blaney D.D., Cheng A.C., Currie B.J., Dance D., Gee J.E., Larsen J., Limmathurotsakul D., Morrow M.G., Norton R, O’Mara E., Peacock S.J., Pesik N., Rogers L.P., Schweizer HP, Steinmetz I., Tan G., Tan P., Wiersinga W.J, Wuthiekanun V., Smith T.L. Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010. Emerg Infect Dis. 2012 Dec; 18(12): e2. doi: 10.3201/eid1812.120638. PMID: 23171644; PMCID: PMC3557896.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.


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Cite this article

Vishnu M., Rigen Jyoti Kalita, Tandra Biswas. Melioidosis with Involvement of CNS: A Case Report in Northeast India. Ind J Emerg Med. 2025; 11(1): 59-62.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


Received Accepted Published
November 15, 2024 December 27, 2024 March 30, 2025

DOI: https://doi.org/10.21088/ijem.2395.311X.11125.9

Keywords

MelioidosisBurkholderia pseudomalleiBrain abscess

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Received November 15, 2024
Accepted December 27, 2024
Published March 30, 2025

licence


Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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