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Ketamine Therapy in Psychiatry: A Comprehensive Review

Asif Khan , Asif Khan1 , Satyaveer2 , Shrikant K Nair3 , Deepali Gaikwad Joseph4

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Journal of Psychiatric Nursing 14(1):p 31-36, Jan- April 2025. | DOI: 10.21088/jpn.2277.9035.14125.5

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Asif Khan, Satyaveer, Shrikant K Nair, Deeksha Srivastava et. al, Ketamine Therapy in Psychiatry: A Comprehensive Review. J Psychiatr Nurs. 2025; 14(1): 31–36.
 

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Abstract

Ketamine, traditionally known as an anesthetic agent, has garnered attention for its rapid acting antidepressant properties, particularly in patients with treatment resistant depression (TRD). The compound’s unique pharmacological profile primarily as an NMDA receptor antagonist has enabled its repositioning in psychiatric settings, where conventional antidepressants often fall short. This review delves into the evolving role of ketamine in psychiatry, examining its mechanisms of action, therapeutic applications, clinical efficacy, safety concerns, and emerging trends in the field. While ketamine therapy offers promise, its use raises ethical, regulatory, and long-term safety considerations that require continued research and careful implementation.
 

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All authors contributed significantly to the work and approve its publication

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This article does not involve any human or animal subjects, and therefore does not require ethics approval

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Cite this article

Asif Khan, Satyaveer, Shrikant K Nair, Deeksha Srivastava et. al, Ketamine Therapy in Psychiatry: A Comprehensive Review. J Psychiatr Nurs. 2025; 14(1): 31–36.
 

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DOI: 10.21088/jpn.2277.9035.14125.5

Keywords

Ketamine • Psychiatry • Depression • NMDA receptor • Antidepressant Treatment-resistant depression • Mental health • Suicidality • Glutamatergic system • Neuroplasticity

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