Abstract

Recurrent seizures and a substantial psychosocial cost are hallmarks of epilepsy, a chronic neurological condition. Almost one-third of individuals still have drug-resistant epilepsy or unfavorable treatment side effects despite advancements in antiepileptic medication. These difficulties have prompted research into supplementary therapies like yoga. With an emphasis on clinical results, neurophysiological mechanisms, and methodological quality, this systematic and narrative-integrative review summarizes peer-reviewed research on yoga therapies in epilepsy. Clinical and mechanistic research published between 1980 and 2025 were found using a PRISMA 2020-aligned search of key biomedical databases. According to research, yoga may provide further advantages for autonomic regulation, stress reduction, seizure management, and quality of life. However, methodological constraints and variation call for more thorough testing and careful interpretation.

• 1.   World Health Organization. Epilepsy: A Public Health Imperative. World Health Organization, 2019.
• 2.   Kwan, Patrick, Alexis Arzimanoglou, Anne T. Berg, Martin J. Brodie, Wiebe S. de Boer, Emilio Perucca, Samuel Wiebe, and Jacqueline A. French. “Definition of Drug Resistant Epilepsy: Consensus Proposal by the ILAE Task Force.” Epilepsia, vol. 51, no. 6, 2010, pp. 1069–1077. https://doi.org/10.1111/j.1528- 1167.2009.02397.x
• 3.   Engel, Jerome. Seizures and Epilepsy. 2nd ed., Oxford University Press, 2013.
• 4.   Panjwani, Usha, K. Selvamurthy, N. Singh, R. Gupta, R. Mukhopadhyay, and R. Thakur. “Effect of Sahaja Yoga Practice on Seizure Control and EEG Changes in Patients with Epilepsy.” Indian Journal of Medical Research, vol. 103, 1996, pp. 165–172.
• 5.   Telles, Shirley, Raghavendra Nagarathna, and H. R. Nagendra. “Autonomic Changes during ‘OM’ Meditation.” Indian Journal of Physiology and Pharmacology, vol. 41, no. 4, 1997, pp. 418–420.
• 6.   Sarang, Shashikala P., and Shirley Telles. “EEG Patterns during Meditation.” Applied Psychophysiology and Biofeedback, vol. 31, no. 1, 2006, pp. 75–81. https://doi.org/10.1007/ s10484-006-9001-5
• 7.   Streeter, Chris C., Patrick L. Gerbarg, Richard P. Brown, Jeffrey M. Saper, Samuel S. Ciraulo, and R. Murali Doraiswamy. “Effects of Yoga on the Autonomic Nervous System, GammaAminobutyric Acid, and Allostasis.” Medical Hypotheses, vol. 78, no. 5, 2012, pp. 571–579. https://doi.org/10.1016/j.mehy.2012.01.021
• 8.   Rajesh, Kannan, K. Sathyaprabha, Raghavendra Nagarathna, and H. R. Nagendra. “Effect of Yoga Practice in the Management of Epilepsy.” Neurology India, vol. 54, no. 3, 2006, pp. 355– 357.
• 9.   Lundgren, Tobias, Joanne Dahl, Niklas Yardi, and Carl-Göran Melin. “Acceptance and Commitment Therapy and Yoga for DrugRefractory Epilepsy.” Epilepsy & Behavior, vol. 13, no. 1, 2008, pp. 102–108. https://doi. Akhilesh, Jayvindra Singh. Integrative Role of Yogic Interventions in Epilepsy Management: A Systematic and Comprehensive Review188 IJAMY / Volume 19 Number 1/July - September 2026 Indian Journal of Ancient Medicine and Yoga org/10.1016/j.yebeh.2008.02.009
• 10.   Cramer, Holger, Romy Lauche, Gustav Dobos, Thomas Langhorst, and Jost Langhorst. “Yoga for Quality of Life and Mental Health.” PLOS ONE, vol. 8, no. 10, 2013, e75522. https://doi. org/10.1371/journal.pone.0075522
• 11.   McEwen, Bruce S. “Physiology and Neurobiology of Stress and Adaptation.” Physiological Reviews, vol. 87, no. 3, 2007, pp. 873–904. https://doi.org/10.1152/ physrev.00041.2006
• 12.   Devinsky, Orrin, Daniel Friedman, and Eric Marsh. “Complementary and Alternative Medicine in Epilepsy.” The Lancet Neurology, vol. 17, no. 12, 2018, pp. 119–131. https://doi. org/10.1016/S1474-4422(18)30329-1
• 13.   Fisher, Robert S., Jacqueline A. French, James W. H. Jacobs, and Stephen Schachter. “Reliability of Seizure Diaries.” Epilepsy Research, vol. 85, no. 1, 2009, pp. 90–94. https:// doi.org/10.1016/j.eplepsyres.2009.02.005
• 14.   Büssing, Arndt, Andreas Michalsen, Sat Bir S. Khalsa, Shirley Telles, and Karen J. Sherman. “Effects of Yoga on Mental and Physical Health: A Short Summary of Reviews.” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 165410. https:// doi.org/10.1155/2012/165410
• 15.   Saper, Robert B., David M. Eisenberg, Russell S. Davis, and Roger B. Phillips. “Yoga Injuries: A Review of the Literature.” Annals of Internal Medicine, vol. 162, no. 1, 2015, pp. 47–56. https://doi.org/10.7326/M14-1231
• 16.   George, Manju, Santhosh Nair, and P. Sarma. “Yoga for Refractory Epilepsy: A Controlled Trial.” Seizure, vol. 25, 2015, pp. 1–7. https:// doi.org/10.1016/j.seizure.2014.09.004
• 17.   Khalsa, Sat Bir S. “Yoga as a Therapeutic Intervention: A Bibliometric Analysis of Published Research Studies.” Progress in Brain Research, vol. 213, 2014, pp. 249–269. https:// doi.org/10.1016/B978-0-444-63326-2.00013-2
• 18.   Tripathi, V., Bhaskar, L., Kharya, C., Bhatia, M., & Kochupillai, V. (2025). Unlocking deep relaxation: the power of rhythmic breathing on brain rhythms. npj Mental Health Research, 4(1), 39.
• 19.   Löscher, Wolfgang. “Translational Research in Epilepsy: From Animal Models to the Clinic.” Nature Reviews Neurology, vol. 13, no. 4, 2017, pp. 205–220. https://doi.org/10.1038/ nrneurol.2017.20
• 20.   Iyengar, Bellur Krishnamachar Sundararaja. Light on Yoga. Schocken Books, 1979.
• 21.   Saraswati, Swami Satyananda. Yoga Yoga Publications Trust, 2009.
• 22.   Kaur, Kirandeep, et al. “Effectiveness of yoga intervention in reducing felt stigma in adults with epilepsy: a randomized controlled trial.” Neurology 101.23 (2023): e2388-e2400.
• 23.   Barnard, Sarah N., et al. “The adverse effects of commonly prescribed antiseizure medications in adults with newly diagnosed focal epilepsy.” Neurology 103.7 (2024): e209821.
• 24.   Helbach, Jasmin, et al. “Reporting according to the preferred reporting items for systematic reviews and meta-analyses for abstracts (PRISMA-A) depends on abstract length.” Journal of Clinical Epidemiology 154 (2023): 167-177.
• 25.   Whittemore, Robin, and Kathleen Knafl. “The Integrative Review: Updated Methodology.” Journal of Advanced Nursing, vol. 52, no. 5, 2005, pp. 546–553. h t t p s : / / d o i . o r g / 1 0 . 1 1 1 1 / j . 1 3 6 5 - 2648.2005.03621.x
• 26.   Telles, Shirley, Raghavendra Nagarathna, and H. R. Nagendra. “Heart Rate Variability Changes during Yoga Practice.” International Journal of Yoga, vol. 3, no. 2, 2010, pp. 62–68. https://doi.org/10.4103/0973-6131.72614
• 27.   Harden, Cynthia L., Kimford J. Meador, and Jacqueline A. French. “Quality of Life in Epilepsy.” Epilepsy & Behavior, vol. 14, no. 1, 2009, pp. 1–7. https://doi.org/10.1016/j. yebeh.2008.09.009
• 28.   Schmidt, Dieter, and Matti Sillanpää. “LongTerm Outcome of Epilepsy.” Epilepsy & Behavior, vol. 25, no. 3, 2012, pp. 305–310. https://doi.org/10.1016/j.yebeh.2012.07.005
• 29.   Campelo, Gabriela, et al. “Long-term effects of yoga-based practices on neural, cognitive, psychological, and physiological outcomes in adults: A scoping review and evidence map.” BMC complementary medicine and therapies 25.1 (2025): 92.
• 30.   Naveen, K. V., Shirley Telles, Raghavendra Nagarathna, and H. R. Nagendra. “Effect of Yoga on Cortisol Levels in Healthy Adults.” Indian Journal of Physiology and Pharmacology, vol. 57, no. 4, 2013, pp. 427–432. DOI: Not assigned.
• 31.   Singh, Shweta, P. B. Jayaram, and Santho Nair. “Yoga Therapy Improves Sleep Quality in Patients with Epilepsy.” Epilepsy Research, vol. 127, 2016, pp. 159–164 https://doi.org/10.1016/j.eplepsyres. 2016.09.007.
• 33.   Tang, Yi-Yuan, Britta K. Hölzel, and Michael I. Posner. “The Neuroscience of Mindfulness Meditation.” Nature Reviews Neuroscience, vol. 16, no. 4, 2015, pp. 213–225. https://doi. org/10.1038/nrn3916
• 34.   Kariuki, Symon M., and Charles RJC Newton. “Integrating alternative and complementary medicine in the management of epilepsy and its comorbidities in low-and middle-income settings.” Epilepsy & Behavior 162 (2025): 110172.
• 35.   Sharma, Manoj, S. P. Sahoo, and S. R. Rao. “Yoga as an Adjunct Therapy in Epilepsy.” Journal of Neurosciences in Rural Practice, vol. 10, no. 2, 2019, pp. 234–239. https://doi. org/10.4103/jnrp.jnrp_401_18
• 36.   Meador, Kimford J. “Cognitive Effects of Epilepsy Treatment.” Epilepsy & Behavior, vol. 8, no. 1, 2006, pp. 1–9. https://doi.org/10.1016/j. yebeh.2005.11.004
• 37.   Hassed, Craig, Richard Chambers, and John B. Evans. “Mindfulness in Health Care.” Medical Journal of Australia, vol. 191, no. 6, 2009, pp. 357– 360. https://doi.org/10.5694/j.1326-5377.2009. tb02860.x
• 38.   Ernst, Edzard. “Complementary Medicine: Evidence-Based Review.” Medical Journal of Australia, vol. 184, no. 4, 2006, pp. 152–154. https://doi.org/10.5694/j.1326-5377.2006. tb00154.x
• 39.   Goyal, Madhav, Sonal Singh, Erica M. Sibinga, Neda F. Gould, Anastasia Rowland-Seymour, Ritu Sharma, Zachary Berger, Dana Sleicher, David D. Maron, Hasan M. Shihab, Paul D. Ranasinghe, and Robert B. Haythornthwaite. “Meditation Programs for Psychological Stress and Well-Being.” JAMA Internal Medicine, vol. 174, no. 3, 2014, pp. 357–368. https://doi. org/10.1001/jamainternmed.2013.13018 40. Gupta, Ravi, Sandeep Grover, and Ajit Avasthi. “Yoga and Neuroplasticity: A Review.” Annals of Neurosciences, vol. 27, no. 1, 2020, pp. 1–10. https://doi.org/10.1177/0972753120909811
• 41.   Pal, Ranjan, Shirley Telles, Raghavendra Nagarathna, and H. R. Nagendra. “EEG Coherence Changes after Yoga Practice.” Clinical EEG and Neuroscience, vol. 45, no. 4, 2014, pp. 260–265. https://doi. org/10.1177/1550059413508121
• 42.   Dash, Manoj, and Shirley Telles. “Yoga Training and Epilepsy.” Indian Journal of Physiology and Pharmacology, vol. 45, no. 3, 2001, pp. 384–388.
• 43.   Narasimhan, Lakshmi, Santhosh Nair, and P. Sarma. “Yoga-Based Interventions in Epilepsy.” Epilepsy & Behavior Reports, vol. 16, 2021, article 100450. https://doi.org/10.1016/j. ebr.2021.100450
• 44.   McCaffrey, Robert J., and John A. Ruff. “Electroencephalographic Correlates of Meditation.” Clinical EEG, vol. 29, no. 4, 1998, pp. 221–228. https://doi. org/10.1177/155005949802900407
• 45.   Patel, Nitin K., Rakesh K. Chandra, and R. K. Sharma. “Integrative Approaches in Neurology.” Neurology India, vol. 66, no. 6, 2018, pp. 1620–1628.

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