Abstract

Every new day come up with different challenges in healthcare sector in developing country like us. So this review article tells us the role of meta-analysis in current healthcare share and current health problems dealing with ‘Evidence Based Medicine Practices’. This article is the combination of healthcare practices and meta-analysis in the field of medicine. Consideration of current trends and scenario demonstrates a consistently increase in use of meta analysis especially in randomized controlled trials and interventional studies. Meta analyses look for new information in existing data. Comparing the results of meta analyses with subsequent findings from large scale, well conducted, randomised controlled trials (so called RCT’s) is one way to assess the validity of this new knowledge. Such comparisons have yielded mixed findings thus far, with good agreement in the majority of cases but notable inconsistencies in others. One such exercise, for example, resulted in the publication of a paper titled "Lessons from a "successful, safe, simple intervention" that wasn't" misleading meta analysis (use of metformin after diabetes mellitus). The inadequacies in meta analyses that have been later challenged by data from RCT’s can often be discovered with the benefit of hindsight. So this article directly or indirectly helps to researchers to adopt new knowledge in Meta analysis especially for current healthcare practice. We can’t separate them as healthcare and meta analysis both are the two sides of a same coin.

• 1.   David Taylor, The pharmaceutical industry and the future of drug development, in pharmaceuticals in the environment, 2015, pp. 1-33.
• 2.   Chokshi, M., Patil, B., Khanna, R., Neogi, S. B., Sharma, J., Paul, V. K., &Zodpey, S. (2016). Health systems in India. Journal of perinatology: official journal of the California Perinatal Association, 36(s3), S9–S12.
• 3.   Haidich A. B. (2010). Meta-analysis in medical research. Hippokratia, 14(Suppl 1), 29–37.
• 4.   Mikolajewicz N, Komarova SV. Meta-analytic methodology for basic research: a practical guide. Frontiers in physiology. 2019 Mar 27; 10:203.
• 5.   Tawfik GM, Dila KA, Mohamed MY, Tam DN, Kien ND, Ahmed AM, Huy NT. A step by step guide for conducting a systematic review and meta-analysis with simulation data. Tropical medicine and health. 2019 Dec; 47(1):1-9.
• 6.   Centre for Cognitive Ageing and Cognitive Epidemiology (2019). Systematic reviews and metaanalyses: a step-by-step guide. [Online]. 2019.
• 7.   Riley RD, Lambert PC, Abo-Zaid G. Meta-analysis of individual participant data: rationale, conduct, and reporting. BMJ 2010; 340: c221.
• 8.   George A Kelly, Kristi S Kelly, and Statistical Models for Meta-Analysis: A brief tutorial, World J Methodol 2012 August 26; 2(4): 27-32.
• 9.   Olkin I, Sampson A. Comparison of meta-analysis versus analysis of variance of individual patient data. Biometrics 1998; 54: 317-322.
• 10.   Cooper H, Patall EA. The relative benefits of metaanalysis conducted with individual participant data versus aggregated data. Psychol Methods 2009; 14: 165-176.
• 11.   Simmonds MC, Higgins JP: Covariate heterogeneity in meta-analysis: criteria for deciding between meta-regression and individual patient data. Stat Med 2007, 26:2982–2999.
• 12.   Simmonds MC, Higgins JP, Stewart LA, Tierney JF, Clarke MJ, and Thompson SG: Meta-analysis of individual patient data from randomized trials: a review of methods used in practice. Clin Trials 2005, 2:209–217.
• 13.   Littell JH, Corcoran J, Pillai V. Systematic reviews and meta-analysis. New York: Oxford University Press, 2008: 120.
• 14.   Borenstein M, Hedges LV, Higgins JP, Rothstein HR, A basic introduction to fixed-effect and random-effects models for meta-analysis, Res Synth Methods. 2010 Apr; 1(2):97-111.
• 15.   Der Simonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177–188.
• 16.   Importance of meta-analysis in medical research, by pubrica-academy, January 8, 2021.
• 17.   Singal, A., Higgins, P., Waljee, A. (2014). A primer on effectiveness and efficacy trials. Clinical and Translational Gastroenterology, 5(1).
• 18.   Moore, Z. (2012). Meta-analysis in context. Journal of Clinical Nursing, 21(19):2798-2807.
• 19.   Metelli S, Chaimani A. Challenges in meta-analyses with observational studies. Evidence-based mental health. 2020 May 1; 23(2):83-7.
• 20.   Eysenck HJ. Meta-analysis and its problems. BMJ. 1994 Sep 24; 309(6957):789-92. doi: 10.1136/bmj.309.6957.789. PMID: 7950571; PMCID: PMC2541015.

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