Abstract

Angiofibromas, accounting for a mere 0.05-0.5% of all head and neck neoplasms, are uncommon benign tumors originating from connective tissue and characterized by a high vascularity and local aggressiveness. Juvenile Nasopharyngeal Angiofibroma, extensively discussed in medical literature, represents the most common subtype and is typically found in the nasopharynx. Extra-nasopharyngeal angiofibromas, which occur in locations outside the nasopharynx, are quite rare, with the maxillary sinus being the most typical site according to existing research. This paper presents a unique case of Extra-nasopharyngeal Angiofibroma affecting the hard palate in an adult female. This case is noteworthy due to the tumor's anterior hard palate location, its occurrence in a female patient, and its clinical resemblance to a fibroma, making it the first reported case of its kind.

• 1.   Capodiferro S, Favia G, Lacaita MG, Muzio LL, Maiorano E. Juvenile angiofibroma: report of a case with primary intra-oral presentation. Oral Oncology Extra 2005 Jan 1;41(1):1-6. DOI: https:// doi.org/10.1016/j.ooe.2004.09.001.
• 2.   Abboud FZ, Youssoufi MA, Zoukal S, Bouhafa T, Hassouni K. Recurrent pterygo-palatal angiofibroma with intracranial extension: case report. Pan Afr Med J 2020 Jun 25;36(1): 128. DOI: 10.11604/pamj.2020.36.128.22435.
• 3.   Mahajan A, Gupta K. Juvenile Nasopharyngeal Angiofibroma [Internet]. Pharynx - Diagnosis and Treatment. Intech Open; 2021. DOI: 10.5772/ intechopen.95923.
• 4.   Ganguly S, Gawarle SH, Keche PN. ExtraNasopharyngeal Angiofibroma in a Pre-Pubertal Child. J Clin Diagn Res 2017 Oct 1;11(10). DOI: 10.7860/JCDR/2017/27897.10771.
• 5.   Singh GB, Agarwal S, Arora R, Doloi P, Kumar D. A rare case of angiofibroma arising from inferior turbinate in a female. JClin Diagn Res 2016 Apr; 10(4):MD07. DOI: 10.7860/JCDR/2016/18548.7621.
• 6.   Yan YY, Lai C, Wu L, Fu Y. Extranasopharyngeal angiofibroma in children: A case report. World J Clin Cases 2022 Jul 7;10(21):7429. DOI: 10.12998/ wjcc.v10.i21.7429.
• 7.   Antoniades K, Antoniades DZ, Antoniades V. Juvenile angiofibroma: report of a case with intraoral presentation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Aug 1;94(2):228-32. DOI: https://doi.org/10.1067/moe.2002.125582.
• 8.   Arora K, Muraleedharan M, Bansal S. Juvenile Nasopharyngeal Angiofibroma with Midline Palatal Ulceration: A Rare Presentation. J Postgrad Med EduRes 2021;55(3):136-8. DOI:10.5005/jpjournals-10028-1436.
• 9.   Kabot TE, Goldman ME, Bergman S, Schwartz RD. Juvenile nasopharyngeal angiofibroma: an unusual presentation in the oral cavity. Oral Surg Oral Med Oral Pathol 1985 May 1;59(5):453-7. DOI: 10.1016/0030-4220(85)90080-5.
• 10.   Nandhini J, Ramasamy S, Kaul RN, Austin RD. Juvenile primary extranasopharyngeal angiofibroma, presenting as cheek swelling. J Oral Maxillofac Pathol 2018 Jan; 22 (Suppl 1):S73-S76. DOI: 10.4103/jomfp.JOMFP_43_17.
• 11.   Nabila A, Sumarta NP, Prasetio O. A rare case of angiofibroma mimicking fibrous epulis in posterior gingival mucosa. Acta Medica Philippina 2021 Nov 24; 55(8). DOI: https://doi.org/10.47895/ amp.v55i8.2128.

Data Sharing Statement

Funding