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Emerging Resistance in Cases of Septicemia with Special Reference to Vancomycin

Kondle Raghu, Head of Clinical Services & Senior Consultant, Department of Emergency & Critical Care Medicine, Narayana Medical College and Hospital, Nellore. Andhra Pradesh 524003, India. , Kondle Raghu1 , M. Shabnum2

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Indian Journal of Emergency Medicine 4(2):p 125-130, April-June 2018. | DOI: http://dx.doi.org/10.21088/ijem.2395.311X.4218.10

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Abstract

Introduction: Blood Stream Infections increase the mortality rate, prolonging hospital stay in ICU, posing a challenge to the skill of not only the clinician but also to the microbiologist. Easy availability and indiscriminate use of antibiotics is leading to antimicrobial resistance.

Objective: To review the spectrum of organisms isolated and their antibiotic sensitivity pattern in the Intensive Care Unit to minimize the risk of morbidity and mortality.

Method: 235 suspected cases of septicemia from ICU were taken; co morbid illness and outcome were noted. Blood culture and their antibiotic susceptibility profile were done.

Results: Of the 235 suspected cases, 47 (20%) were culture positive with Gram Negative Organisms predominant (70.21%) over Gram Positive Organism (27.65%). Klebsiella species was the most common organism isolated (38.29%). Of the 13 GPC, 38.46% cases showed Vancomycin resistance.

Conclusion: Gram Negative Organisms were most common etiological agents with Klebsiella being most predominant. The rate of Vancomycin resistance from isolated organisms was high. Mortality rate was high (17.02%). 

Keywords: Septicemia; Intensive Care Unit; Mortality; Vancomycin; Klebsiella.

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DOI: http://dx.doi.org/10.21088/ijem.2395.311X.4218.10

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