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Indian Journal of Anesthesia and Analgesia

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Efficacy of Intravenous Fentanyl Citrate 2 Microgram/Kg Body Weight Administered before Laryngoscopy and Endotracheal Intubation to Attenuate Hemodynamic Response in Normotensive Individuals

Karande Anuradha S., Dept. of Anaesthesia, Ashwini Rural Medical College Hospital and Research Centre, Kumbhari, Maharashtra 413006. , Karande Anuradha S.* , Dabade Vaishali V.**

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Indian Journal of Anesthesia and Analgesia 4(2):p 415-420, April - June 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.9

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Abstract

Introduction: Laryngoscopy and intubation results in a stimulation of larynx, pharynx, epipharynx and trachea, which are extensively innervated by autonomic nervous system. The parasympathetic supply is via the vagus and sympathetic supply via superior cervical ganglion. Fentanyl seem to provide minute to minute haemodynamic control from intubation to recovery. Aims and Objective: To determine efficacy of intravenous fentanyl 2 microgram/kg body weight administered before laryngoscopy and endotracheal intubation in attenuating the changes in the hemodynamic parameters in normotensiv individuals Methods: Sixty normotensive patients of both sexes, aged between 18-65 years belonged to ASA physical status 1, free from intercurrent cardiovascular and neurological disease were posted for elective surgical procedures under general anaesthesia requiring orotracheal intubation were selected. Patients were informed. Written consent was obtained and the study protocol was approved by the Institutional Ethical committee. Results: When compared with control group, the rise in pulse rate in group II was significantly smaller (p<0.001) a all instances  except at 30 sec (p>0.5), increase in mean systolic blood pressure in group II was significantly smaller (p<0.001) at all instances except at 5 min, increase in diastolic blood pressure in group II was significantly smaller (p<0.001), rise in mean arterial pressure in group II was significantly smaller(p<0.001) at all instances except 5 min, rise in rate pressure product in group II was significantly small (p<0.05) Conclusion: Thus fentanyl in addition to its narcotic analgesic activity is addition to anaesthesiologist’s armamentarium for attenuation of sympathetic stimulation by laryngoscopy and endotracheal intubation.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.9

Keywords

Fentanyl; Laryngoscopy; Endotracheal Intubation; Normotensive.

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