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Effect of Administration of Magnesium Sulphate, Clonidine or Dexmedetomidine on Hemodynamics Due to Pneumoperitoneum in Patients undergoing Laparoscopic Procedures under General Anesthesia

Upinder Kaur, Associate Professor, Department of Anesthesiology and Intensive Care, Adesh Institute of Medical Sciences and Research (AIMSR), Bathinda, Punjab 151109, India. , Upinder Kaur1 , Minnu Panditrao2 , Johnpal Singh Sidhu3 , M.M. Panditrao4

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Indian Journal of Anesthesia and Analgesia 5(2):p 294-302, February 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5218.24

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Abstract

Title: Effect of administration of Magnesium sulphate, Clonidine or Dexmedetomidine on hemodynamics due to pneumoperitoneum in patients undergoing laparoscopic procedures under general anesthesia. Background: Pneumoperitoneum and the positioning during laparoscopy induce pathophysiological changes which potentially complicate anesthetic management and require some intervention. Aim: To compare the effects of Magnesium sulphate (MgSO4), clonidine, or dexmedetomidine on hemodynamic changes occurring after pneumoperitoneum in laparoscopic procedures. Material and Method: 60 adult, ASA Grade I & II, patients undergoing laparoscopies were randomly divided into three groups: Group M (magnesium sulphate), Group D (Dexmedetomidine) & Group C (Clonidine). In each group, boluses of study drugs were given before induction of anesthesia, followed by infusion prior to pneumoperitoneum. Heart rate, systolic/diastolic/mean blood pressure, end tidal CO2, sedation score, VAS score for pain were recorded. Mean and standard deviation for each parameter was calculated using ANOVA. Sedation and pain (VAS) Score were calculated by Kruskal Willis test, p value<0.05 was considered statistically significant’. Results: Intraoperative heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were below baseline & comparable in all three groups (p<0.05) but minimally disturbed in dexmedetomidine group. Most of the patients were pleasantly sedated at the extubation with maximum patients responding to verbal commands quickly in clonidine group. VAS Pain score were minimal in dexmedetomidine group.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5218.24

Keywords

Laparoscopy; Pneumoperitoneum; Hemodynamic; Magnesium Sulphate; Dexmedetomidine; Clonidine. 

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