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E. Coli and Klebsiella Pneumoniae are Major Culprits in CatheterAssociated Urinary Tract Infections, Exhibiting an Increasing Trend in Drug Resistance

Lalfakmawia Benjamin, Upendra Baitha, Piyush Ranjan, Amandeep Singh, Arvind Kumar, Akriti Arora, Shikhar Gupta, Manish Soneja, Sarita Mohapatra, M.A. Khan, Ashutosh Biswas, Purva Mathur, Naveet Wig

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Indian Journal of Preventive Medicine 13(1):p 9-16, Jan-June 2025. | DOI: 10.21088/ijpm.2321.5917.13125.2

How Cite This Article:

Lalfakmawia Benjamin, Upendra Baitha, Piyush Ranjan, et al. E. Coli and Klebsiella Pneumoniae are Major Culprits in Catheter-Associated Urinary Tract Infections, Exhibiting an Increasing Trend in Drug Resistance. J Prev Med. 2025; 13(1): 09-16.

Timeline

Received : July 05, 2025         Accepted : August 08, 2025          Published : June 18, 2025

Abstract

Background and Objective: Catheter-Associated Urinary Tract Infections (CAUTI) are a primary concern in healthcare, leading to increased mortality and morbidity among critically ill patients. This study aimed to identify uropathogens causing CAUTI and assess their antibiotic sensitivity/resistance. Methods: This study was conducted on 100 patients, all aged 18 or above, admitted for more than 48 hours with Foley catheters in place. Microbiologically, we classified the patients confirmed (mCAUTI) and clinically suspected (cCAUTI) based on urine culture results. Results: Out of 100 patients, 21 had positive urine cultures (mCAUTI), while 79 clinically suspected CAUTI cases were culture-negative (cCAUTI). Fever was the most prevalent symptom (67 patients), followed by genitourinary complaints, shock, and altered sensorium. Escherichia coli was the primary isolate among mCAUTI cases, followed by Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus spp., Enterobacter, and Pseudomonas aeruginosa. Imipenem demonstrated the highest sensitivity against gram-negative isolates, while grampositive isolates exhibited significant drug resistance. Conclusion: The study highlights E. coli and emerging Klebsiella pneumoniae as major CAUTI culprits with rising drug resistance. Urgent, cautious antibiotic practices are vital. Limiting catheter use, stringent aseptic measures, and timely removal are key to reducing CAUTI. Imipenem stands out as the most effective antibiotic, urging its careful use against CAUTI-causing pathogens.

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Data Sharing Statement

There are no additional data available.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

Information not provide.

Conflicts of Interest

The authors report no conflicts of interest in this work.

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Cite this article

Lalfakmawia Benjamin, Upendra Baitha, Piyush Ranjan, et al. E. Coli and Klebsiella Pneumoniae are Major Culprits in Catheter-Associated Urinary Tract Infections, Exhibiting an Increasing Trend in Drug Resistance. J Prev Med. 2025; 13(1): 09-16.

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Received Accepted Published
July 05, 2025 August 08, 2025 June 18, 2025
DOI: 10.21088/ijpm.2321.5917.13125.2

Keywords

Catheter-associated Urinary Tract InfectionsEnterobacteriaceaeAntibiotic resistanceCatheterizationImipenem

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Timeline

Received July 05, 2025
Accepted August 08, 2025
Published June 18, 2025

licence

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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